Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru.

Q1 Medicine

Wellcome Open Research Pub Date : 2025-03-18 eCollection Date: 2024-01-01 DOI:10.12688/wellcomeopenres.23077.3

Renzo A Agurto-García, Enrique S Nuñez-Del-Arco, Rodrigo M Carrillo-Larco, J Jaime Miranda, Antonio Bernabe-Ortiz

{"title":"Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru.","authors":"Renzo A Agurto-García, Enrique S Nuñez-Del-Arco, Rodrigo M Carrillo-Larco, J Jaime Miranda, Antonio Bernabe-Ortiz","doi":"10.12688/wellcomeopenres.23077.3","DOIUrl":null,"url":null,"abstract":"Background: The skeletal muscle has mainly a structural function and plays a role in human's metabolism. Besides, the association between sleep quality and muscle mass, in the form of sarcopenia, has been reported. This study aimed to assess whether changes of skeletal muscle mass (SMM) over time are associated with baseline sleep duration and disturbances in a resource-constrained adult Peruvian population.Materials and methods: Secondary analysis using information of a population-based intervention. The outcome was SMM assessed using bioimpedance and the second version of the Lee's formula. The exposures were baseline self-reported sleep duration (normal, short and long sleepers) and disturbances (sleep difficulties and awakening at nights). Crude and adjusted linear mixed models were used to assess the associations of interest, and coefficients (β) and 95% confidence intervales (95% CI) were reported.Results: Data from 2,310 individuals at baseline, mean age 43.4 (SD: 17.2), and 1,163 (50.4%) females were analyzed. Sleep duration was 7.8 (SD: 1.3) hours/day, with 15.3% short sleepers and 11.6% long sleepers, whereas 24.2% reported sleep difficulties and 25.1% awakening at nights. In multivariable model, SMM among short and long sleepers did not vary significantly over time using the Lee's formula; however, SMM was lower at the end of follow-up for long sleepers using bioimpedance (-0.26 kg; 95% CI: -0.47 to -0.06). Sleep disturbances were associated with a gradual SMM reduction: 0.36 kg using bioimpedance and 0.25 kg using the formula at the end of follow-up.Conclusions: Using bioimpedance and formula estimations, sleep disturbances were associated with a reduction of SMM over a period of 2.4 years. Regarding sleep duration, no SMM changes over time were seen in short sleepers, but findings were discordant in long sleepers: a reduction of SMM using bioimpedance, but no change using the formula.","PeriodicalId":23677,"journal":{"name":"Wellcome Open Research","volume":"9 ","pages":"565"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757916/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wellcome Open Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12688/wellcomeopenres.23077.3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The skeletal muscle has mainly a structural function and plays a role in human's metabolism. Besides, the association between sleep quality and muscle mass, in the form of sarcopenia, has been reported. This study aimed to assess whether changes of skeletal muscle mass (SMM) over time are associated with baseline sleep duration and disturbances in a resource-constrained adult Peruvian population.

Materials and methods: Secondary analysis using information of a population-based intervention. The outcome was SMM assessed using bioimpedance and the second version of the Lee's formula. The exposures were baseline self-reported sleep duration (normal, short and long sleepers) and disturbances (sleep difficulties and awakening at nights). Crude and adjusted linear mixed models were used to assess the associations of interest, and coefficients (β) and 95% confidence intervales (95% CI) were reported.

Results: Data from 2,310 individuals at baseline, mean age 43.4 (SD: 17.2), and 1,163 (50.4%) females were analyzed. Sleep duration was 7.8 (SD: 1.3) hours/day, with 15.3% short sleepers and 11.6% long sleepers, whereas 24.2% reported sleep difficulties and 25.1% awakening at nights. In multivariable model, SMM among short and long sleepers did not vary significantly over time using the Lee's formula; however, SMM was lower at the end of follow-up for long sleepers using bioimpedance (-0.26 kg; 95% CI: -0.47 to -0.06). Sleep disturbances were associated with a gradual SMM reduction: 0.36 kg using bioimpedance and 0.25 kg using the formula at the end of follow-up.

Conclusions: Using bioimpedance and formula estimations, sleep disturbances were associated with a reduction of SMM over a period of 2.4 years. Regarding sleep duration, no SMM changes over time were seen in short sleepers, but findings were discordant in long sleepers: a reduction of SMM using bioimpedance, but no change using the formula.

查看原文本刊更多论文

睡眠时间、睡眠障碍和骨骼肌质量随时间的变化：秘鲁一项基于人口的纵向分析。

背景：骨骼肌主要具有结构功能，在人体代谢中起作用。此外，睡眠质量和肌肉质量之间的联系，以肌肉减少症的形式，已经有报道。本研究旨在评估资源受限的秘鲁成年人群骨骼肌质量（SMM）随时间的变化是否与基线睡眠持续时间和障碍有关。材料和方法：利用基于人群的干预信息进行二次分析。结果是使用生物阻抗和第二版Lee公式来评估SMM。暴露是自我报告的基线睡眠时间（正常睡眠者、短睡眠者和长睡眠者）和干扰（睡眠困难和夜间醒来）。使用粗糙和调整后的线性混合模型来评估感兴趣的相关性，并报告系数（β）和95%置信区间（95% CI）。结果：分析了2310例基线数据，平均年龄43.4岁（SD: 17.2）， 1163例（50.4%）女性。睡眠时间为7.8 （SD: 1.3）小时/天，其中15.3%为短睡眠者，11.6%为长睡眠者，而24.2%的人报告睡眠困难，25.1%的人夜间醒来。在多变量模型中，使用Lee公式，短睡眠者和长睡眠者的SMM随时间变化不显著；然而，在生物阻抗随访结束时，长睡眠者的SMM较低(-0.26 kg；95% CI: -0.47 ~ -0.06)。睡眠障碍与SMM逐渐减少有关：随访结束时，生物阻抗法减少0.36 kg，公式法减少0.25 kg。结论：使用生物阻抗和公式估计，睡眠障碍与2.4年期间SMM的减少有关。关于睡眠时间，短睡眠者的SMM没有随时间变化，但在长睡眠者中发现不一致：使用生物阻抗减少SMM，但使用公式没有变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Wellcome Open Research Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

5.50

自引率

0.00%

发文量

426

审稿时长

1 weeks

期刊介绍： Wellcome Open Research publishes scholarly articles reporting any basic scientific, translational and clinical research that has been funded (or co-funded) by Wellcome. Each publication must have at least one author who has been, or still is, a recipient of a Wellcome grant. Articles must be original (not duplications). All research, including clinical trials, systematic reviews, software tools, method articles, and many others, is welcome and will be published irrespective of the perceived level of interest or novelty; confirmatory and negative results, as well as null studies are all suitable. See the full list of article types here. All articles are published using a fully transparent, author-driven model: the authors are solely responsible for the content of their article. Invited peer review takes place openly after publication, and the authors play a crucial role in ensuring that the article is peer-reviewed by independent experts in a timely manner. Articles that pass peer review will be indexed in PubMed and elsewhere. Wellcome Open Research is an Open Research platform: all articles are published open access; the publishing and peer-review processes are fully transparent; and authors are asked to include detailed descriptions of methods and to provide full and easy access to source data underlying the results to improve reproducibility.