Suspected Fatal Arrhythmic Events in Japanese Patients With Coronary Artery Disease　- From the CREDO-Kyoto PCI/CABG Registries Cohorts-2 and -3.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation Journal Pub Date : 2025-01-25 DOI:10.1253/circj.CJ-24-0488

Koji Hanazawa, Hiroki Shiomi, Takeshi Morimoto, Kenji Ando, Yutaka Furukawa, Tomohisa Tada, Junichi Tazaki, Kazushige Kadota, Toshihiro Tamura, Yukihito Sato, Mitsuo Matsuda, Moriaki Inoko, Manabu Shirotani, Tomoya Onodera, Eiji Shinoda, Takashi Yamamoto, Takashi Tamura, Shinji Miki, Takeshi Aoyama, Satoru Suwa, Kenji Minatoya, Yoshiharu Soga, Tadaaki Koyama, Tatsuhiko Komiya, Nobuhisa Ohno, Tatsuya Ogawa, Fumio Yamazaki, Junichiro Nishizawa, Jiro Esaki, Naoki Kanemitsu, Yoshihisa Nakagawa, Takeshi Kimura

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引用次数: 0

Abstract

Background: Fatal arrhythmic events (FAEs), such as sudden cardiac death (SCD) and fatal ventricular arrhythmias, are a devastating complication in patients with coronary artery disease (CAD). Therefore, in this study we aimed to assess the incidence of FAEs in more recent Japanese patients with CAD and to examine whether risk stratification of FAEs can still be feasible using the left ventricular ejection fraction (LVEF).

Methods and results: In the CREDO Kyoto PCI/CABG registry cohorts-2 and -3, there were 25,843 patients with LVEF data who received a first coronary revascularization (LVEF ≤35% group: N=1,671, 35%45%: N=21,503). FAEs were defined as a composite of SCD or hospitalization for serious ventricular arrhythmias. The cumulative 5-year incidence of FAEs was 2.4% and it increased with decreasing LVEF (LVEF ≤35%: 8.84%, 35%45%: 1.67%, log-rank P<0.0001). The adjusted risk of FAEs also increased with decreasing LVEF.

Conclusions: LVEF is still a strong independent factor for predicting FAEs in patients with CAD in the PCI era. There was no obvious decrease in the incidence of FAEs between the 2 cohorts. The risk factors for FAEs through the 2 cohorts, other than low LVEF, included age ≥75 years, diabetes, heart failure, hemodialysis, atrial fibrillation, and anemia.

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日本冠状动脉疾病患者的疑似致命性心律失常事件--来自 CREDO-Kyoto PCI/CABG 登记组群-2 和-3。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation Journal 医学-心血管系统

CiteScore

5.80

自引率

12.10%

发文量

471

审稿时长

1.6 months

期刊介绍： Circulation publishes original research manuscripts, review articles, and other content related to cardiovascular health and disease, including observational studies, clinical trials, epidemiology, health services and outcomes studies, and advances in basic and translational research.

Suspected Fatal Arrhythmic Events in Japanese Patients With Coronary Artery Disease - From the CREDO-Kyoto PCI/CABG Registries Cohorts-2 and -3.

Abstract

Suspected Fatal Arrhythmic Events in Japanese Patients With Coronary Artery Disease　- From the CREDO-Kyoto PCI/CABG Registries Cohorts-2 and -3.