Canine cystic astrocytomas: 7 cases.

IF 1.2 3区 农林科学 Q3 VETERINARY SCIENCES
Vicente A Avila Reyes, Andrew D Miller, Alexander de Lahunta, Brian A Summers, Daniel R Rissi
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引用次数: 0

Abstract

Tumoral macrocysts (grossly observable cysts) are common in human pilocytic astrocytomas but are rarely reported in canine astrocytomas. Here we describe 7 canine astrocytomas with macrocysts. The median age of affected patients was 9.6 y, and 2 dogs were brachycephalic. Clinical signs reported in 6 cases included head tilt (4 cases), falling (4 cases), and ataxia (3 cases). Gross changes consisted of well (5 cases) or poorly demarcated (2 cases), tan-to-pale-yellow masses with distinct, 2-10-mm fluid-filled cysts that expanded the cerebellum (4 cases) or telencephalon (3 cases). Histology and immunohistochemistry revealed low-grade astrocytoma in 6 cases and high-grade astrocytoma in 1 case. Neoplastic cells were elongate, formed bundles embedded in an eosinophilic fibrillary stroma, and had oval-to-elongate nuclei. Gemistocytic differentiation was common (4 cases). Cystic areas were lined by neoplastic astrocytes and were either apparently empty or contained scant, eosinophilic, proteinaceous material and a few neoplastic astrocytes, foamy macrophages, and occasionally other leukocytes. The mitotic activity was absent or low across cases. Cytoplasmic immunolabeling for glial fibrillary acidic protein was detected in 6 cases. Our findings indicate that canine cystic astrocytomas are rare (our cases span several decades) and are located mainly, but not exclusively, in the cerebellum.

犬囊性星形细胞瘤:7 例。
肿瘤大囊肿(肉眼可见的囊肿)在人类毛细胞星形细胞瘤中很常见,但在犬星形细胞瘤中很少报道。本文报告7例犬星形细胞瘤伴大囊肿。患者中位年龄为9.6岁,2只犬为短头畸形。6例临床症状包括头部倾斜(4例)、跌倒(4例)、共济失调(3例)。大体改变包括清晰(5例)或界限不清(2例),棕褐色至淡黄色肿块伴明显的2- 10mm充满液体的囊肿,扩张小脑(4例)或脑端(3例)。组织学及免疫组化示低级别星形细胞瘤6例,高级别星形细胞瘤1例。肿瘤细胞呈细长状,成束包裹在嗜酸性原纤维基质中,细胞核呈卵圆形至细长状。双细胞分化常见(4例)。囊性区域排列着肿瘤星形胶质细胞,明显空或含有少量的嗜酸性蛋白物质和少量肿瘤星形胶质细胞、泡沫状巨噬细胞,偶尔也有其他白细胞。有丝分裂活性缺失或低。检测了6例胶质原纤维酸性蛋白的细胞质免疫标记。我们的研究结果表明,犬囊性星形细胞瘤是罕见的(我们的病例跨越几十年),主要位于小脑,但不完全位于小脑。
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来源期刊
CiteScore
3.00
自引率
6.70%
发文量
127
审稿时长
6-16 weeks
期刊介绍: The Journal of Veterinary Diagnostic Investigation (J Vet Diagn Invest) is an international peer-reviewed journal published bimonthly in English by the American Association of Veterinary Laboratory Diagnosticians (AAVLD). JVDI is devoted to all aspects of veterinary laboratory diagnostic science including the major disciplines of anatomic pathology, bacteriology/mycology, clinical pathology, epidemiology, immunology, laboratory information management, molecular biology, parasitology, public health, toxicology, and virology.
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