Lipedema: exploring pathophysiology and treatment strategies - state of the art.

IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE

Jornal Vascular Brasileiro Pub Date : 2025-01-20 eCollection Date: 2024-01-01 DOI:10.1590/1677-5449.202400252

Fabio Kamamoto, Jaqueline Munaretto Timm Baiocchi, Bernardo Nogueira Batista, Renan Diego Américo Ribeiro, Débora Aparecida Oliveira Modena, Vitor Cervantes Gornati

{"title":"Lipedema: exploring pathophysiology and treatment strategies - state of the art.","authors":"Fabio Kamamoto, Jaqueline Munaretto Timm Baiocchi, Bernardo Nogueira Batista, Renan Diego Américo Ribeiro, Débora Aparecida Oliveira Modena, Vitor Cervantes Gornati","doi":"10.1590/1677-5449.202400252","DOIUrl":null,"url":null,"abstract":"<p><p>Lipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.</p>","PeriodicalId":14814,"journal":{"name":"Jornal Vascular Brasileiro","volume":"23 ","pages":"e20240025"},"PeriodicalIF":0.8000,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758576/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jornal Vascular Brasileiro","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/1677-5449.202400252","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

Abstract

Lipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.

查看原文本刊更多论文

脂水肿：探索病理生理学和治疗策略-艺术状态。

脂肪水肿的特征是异常脂肪沉积在手臂、臀部、臀部和大腿等部位，手和脚除外。症状包括疼痛、瘀伤、水肿和皮下结节，这些症状抵抗传统的干预措施，如饮食和运动。尽管越来越多的认识，全面的了解，包括病理生理，临床和治疗方面，还没有完全实现。这篇综述旨在填补这一领域的知识空白，以支持更明智的管理脂水肿。这篇叙述性综述提供了对脂肪水肿治疗的更深层次的理解，解决了病理生理学和治疗选择。这些数据揭示了知识的进步，特别是在保守和手术治疗方面，重点是提高生活质量。然而，缺乏支持各种治疗方法的安全性和有效性的科学证据。需要进一步的研究来确保安全性并提高对这种复杂疾病的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Jornal Vascular Brasileiro Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Jornal Vascular Brasileiro is editated and published quaterly to select and disseminate high-quality scientific contents concerning original research, novel surgical and diagnostic techniques, and clinical observations in the field of vascular surgery, angiology, and endovascular surgery. Its abbreviated title is J. Vasc. Bras., which should be used in bibliographies, footnotes and bibliographical references and strips.