Comprehensive care of ulcerative colitis: new treatment strategies.

IF 3.8 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-01-26 DOI:10.1080/17474124.2025.2457451

Thanaboon Chaemsupaphan, Arteen Arzivian, Rupert W Leong

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引用次数: 0

Abstract

Introduction: Ulcerative colitis is a chronic inflammatory condition of the colon driven by aberrant immune activation. Although advanced medical therapies form the cornerstone of ulcerative colitis management, unmet needs include failure to induce and sustain remission in a substantial proportion of patients and in managing acute severe ulcerative colitis. We review new treatment strategies that might improve patient outcomes in the management of moderate-to-severe ulcerative colitis.

Areas covered: A literature search was conducted using the PubMed database, including studies published from inception to October 2024, selected for their relevance. Recognizing current limitations, this article reviews strategies to improve treatment outcomes in ulcerative colitis using advanced therapies. These approaches include early treatment initiation, dose optimization, positioning newer agents as first-line therapies, combination therapy, targeting novel therapeutic endpoints, and the management of acute severe ulcerative colitis.

Expert opinion: The strategies discussed may contribute to establishing new standards of care aimed at achieving long-term remission and enhancing patient outcomes. Personalized therapy, which tailors treatment based on individual disease characteristics and risk factors, is anticipated to become a critical aspect of delivering more effective care in the future.

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溃疡性结肠炎的综合护理：新的治疗策略。

简介：溃疡性结肠炎是一种由异常免疫激活引起的结肠慢性炎症。虽然先进的医学疗法是溃疡性结肠炎管理的基石，但未满足的需求包括：在相当大比例的患者中未能诱导和维持缓解，以及在急性严重溃疡性结肠炎的管理方面。我们回顾了可能改善中重度溃疡性结肠炎患者治疗结果的新治疗策略。覆盖领域：使用PubMed数据库进行文献检索，包括从成立到2024年10月发表的研究，根据其相关性进行选择。认识到目前的局限性，本文回顾了使用先进疗法改善溃疡性结肠炎治疗结果的策略。这些方法包括早期治疗开始，剂量优化，将新药定位为一线治疗，联合治疗，靶向新的治疗终点，以及急性严重溃疡性结肠炎的管理。专家意见：讨论的策略可能有助于建立新的护理标准，旨在实现长期缓解和提高患者的结果。个性化治疗，即根据个体疾病特征和风险因素量身定制治疗，预计将成为未来提供更有效护理的关键方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Gastroenterology & Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

6.80

自引率

2.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The enormous health and economic burden of gastrointestinal disease worldwide warrants a sharp focus on the etiology, epidemiology, prevention, diagnosis, treatment and development of new therapies. By the end of the last century we had seen enormous advances, both in technologies to visualize disease and in curative therapies in areas such as gastric ulcer, with the advent first of the H2-antagonists and then the proton pump inhibitors - clear examples of how advances in medicine can massively benefit the patient. Nevertheless, specialists face ongoing challenges from a wide array of diseases of diverse etiology.