Global, regional, national epidemiology and trends of Parkinson's disease from 1990 to 2021: findings from the Global Burden of Disease Study 2021.

IF 4.1 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2025-01-10 eCollection Date: 2024-01-01 DOI:10.3389/fnagi.2024.1498756

Yuanrong Luo, Lichun Qiao, Miaoqian Li, Xinyue Wen, Wenbin Zhang, Xianwen Li

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引用次数: 0

Abstract

Aims: In light of the escalating global incidence of Parkinson's disease and the dearth of therapeutic interventions that can alter the disease's course, there exists an urgent necessity to comprehensively elucidate and quantify the disease's global burden.

Methods: This study analyzed the incidence, prevalence, and disability-adjusted life years (DALYs) of Parkinson's disease at global, regional, and national levels based on the Global Burden of Disease Study 2021. Bayesian age-period cohort (BAPC) analysis was used to predict the burden in Parkinson's disease from 2022 to 2035.

Results: In 2021, 11.77 million people worldwide had Parkinson's disease. Age-standardized rates of incidence, prevalence, and DALYs increased to 15.63/100,000, 138.63/100,000, and 89.59/100,000. The burden of Parkinson's disease were higher in males than in females, and showed an increase and then a slight decrease with age. The disease burden was highest in East Asia. BAPC projection showed an increase in all metrics by 2035 except for a slight decrease in the age-standardized DALYs rates.

Conclusion: The global burden of Parkinson's disease has risen over the past 32 years, and there is a need to focus on key populations, as well as to improve health policies to prevent and treat Parkinson's disease.

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.