Withdrawn: Stable Gastric Pentadecapeptide BPC 157 as a Therapy of Severe Electrolyte Disturbances in Rats

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Neuropharmacology Pub Date : 2025-01-24 DOI:10.2174/011570159X349612241205065330

Marija Medvidovic Grubisic, Sanja Strbe, Ivan Barisic, Dijana Balenovic, Vasilije Stambolija, Marin Lozic, Sanja Barsic Ostojic, Ivana Oreskovic, Helena Zizek, Klara Brcic, Luka Coric, Mario Staresinic, Vladimir Blagaic, Lidija Beketic Oreskovic, Zeljka Belosic Halle, Danijel Matek, Dragan Soldo, Boris Grizelj, Alenka Boban Blagaic, Anita Skrtic, Predrag Sikiric, Sven Seiwerth

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引用次数: 0

Abstract

The article has been withdrawn at the author's request from the website of the journal Current Neuropharmacology.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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稳定胃五肽bpc157治疗大鼠严重电解质紊乱。

这篇综述探讨了稳定的胃五肽BPC 157在解决电解质失衡，特别是高钾血症、低钾血症、高镁血症和高脂血症方面的治疗潜力。在高钾血症中，BPC 157显示出对KCl过量（腹腔、灌胃和体外）的全面拮抗作用，有效缓解肌肉无力、高血压、括约肌功能障碍、心律失常和死亡等症状。它还能抵消琥珀胆碱和镁过量的副作用，包括全身肌肉麻痹、心律失常和高钾血症。在低钾血症中，BPC 157（预防性或治疗性，腹腔或灌胃）预防了致命的结局，并解决了速尿引起的低钾血症、心电图改变、房室传导阻滞、室性心律失常和骨骼肌肌阵挛。镁过量后，BPC 157减轻了肌肉无力、脑损伤和高钾血症引起的并发症。体外研究（HEK293细胞）显示BPC 157能够对抗高钾血症和高镁血症诱导的去极化和低钾血症诱导的超极化。在锂中毒中，BPC 157促进侧支通路激活，解决血管和多器官功能衰竭，并抵消晚期Virchow三联症和闭塞样综合征。总的来说，这些发现强调了BPC 157在治疗电解质失衡方面的治疗前景，值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Neuropharmacology 医学-神经科学

CiteScore

8.70

自引率

1.90%

发文量

369

审稿时长

>12 weeks

期刊介绍： Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.