The associations between irregular breakfast and late-night snacking with metabolic dysfunction-associated steatotic liver disease

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition Pub Date : 2025-01-20 DOI:10.1016/j.clnu.2025.01.019

Wenzai Shi , Xiaopeng Suo , Yiming Wang , Nan Yao , Siyu Xing , Pengcheng Wei , Delin Ma , Jiye Zhu , Qingsong Zhang , Zhao Li

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引用次数: 0

Abstract

Background

The newly coined term Metabolic dysfunction-associated steatotic liver disease (MASLD) emphasizes the critical role of metabolic risk factors in the pathogenesis of fatty liver disease. The consumption of irregular breakfasts or late-night snacks has been identified as a factor closely associated with disruptions in the body's energy homeostasis and metabolic balance. However, the relationship between these behaviors and MASLD has not been previously examined.

Methods

Participants in this study were recruited from the Kailuan cohort, a prospective cohort. All participants completed questionnaires regarding breakfast and late-night snack frequencies. The primary outcomes were MASLD and MASLD with increased alcohol intake (MetALD). Cox regression analysis was utilized to calculate the hazard ratios (HR) and 95 % confidence intervals (CI) for MASLD and MetALD in different groups. Mediation analysis was used to assess the mediating effect of BMI on this relationship.

Results

A total of 32,030 participants were included in the study. Both irregular breakfast consumption and late-night snacking were associated with an increased risk of MASLD. Compared to participants who consumed regular breakfast and no late-night snacks, the risk of MASLD was elevated in participants who consumed regular breakfast but late-night snacks (HR = 1.12, 95 % CI: 1.05–1.20), irregular breakfast but no late-night snacking (HR = 1.16, 95 % CI: 1.05–1.27), irregular breakfast and late-night snacking (HR = 1.26, 95 % CI: 1.13–1.42), never ate breakfast and no late-night snacking (HR = 1.33, 95 % CI: 1.23–1.44), and never ate breakfast and late-night snacking (HR = 1.52, 95 % CI: 1.30–1.77).

Conclusion

Irregular or skipped breakfast and late-night snacking were associated with an increased risk of MASLD and MetALD.

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来源期刊

Clinical nutrition 医学-营养学

CiteScore

14.10

自引率

6.30%

发文量

356

审稿时长

28 days

期刊介绍： Clinical Nutrition, the official journal of ESPEN, The European Society for Clinical Nutrition and Metabolism, is an international journal providing essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice. Published bi-monthly, each issue combines original articles and reviews providing an invaluable reference for any specialist concerned with these fields.