Cancer-associated thrombosis: what is new?

IF 2.8 4区 医学 Q2 ONCOLOGY
Current Opinion in Oncology Pub Date : 2025-03-01 Epub Date: 2025-01-16 DOI:10.1097/CCO.0000000000001125
Isabelle Mahé, Samuel Benarroch, Sadji Djennaoui, Rabiaa Hakem, Abdallah Ghorbel, Hélène Helfer, Jean Chidiac
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引用次数: 0

Abstract

Purpose of review: The life expectancy of patients suffering from thrombosis associated with cancer has improved significantly, making them a chronic disease. Patients with thrombosis and cancer are fragile. Treated with anticoagulants, they remain at risk of complications.

Recent findings: Consequently, news issues emerge for clinical practice: anticoagulation therapy personalization is required to optimize the benefit ratio, involving patient characteristics and cancer characteristics. During follow-up, prediction score are designed and investigated to help identify and discriminate patients at risk of venous thromboembolism recurrences and major bleedings. Considering the improved prognosis of patients with cancer and cancer-associated thrombosis, the question of extended treatment arises, representing a major unmet need to date. Finally, new strategies, in particular anti-XI agents that appear attractive options, are currently being evaluated in the treatment of thrombosis associated with cancer.

Summary: The improved prognosis of patients with cancer-associated thrombosis is accompanied by new therapeutic strategies to improve the benefit-risk ratio of anticoagulant treatment in these fragile patients, at risk of both venous thromboembolic recurrence and haemorrhagic complication.

癌症相关血栓:有什么新进展?
回顾目的:癌症相关血栓患者的预期寿命显著提高,成为一种慢性疾病。患有血栓和癌症的病人很脆弱。使用抗凝剂治疗,他们仍然有并发症的风险。因此,临床实践中出现了新的问题:需要抗凝治疗个性化以优化获益比,涉及患者特征和癌症特征。在随访过程中,设计和研究预测评分,以帮助识别和区分有静脉血栓栓塞复发和大出血风险的患者。考虑到癌症和癌症相关血栓患者预后的改善,出现了延长治疗的问题,这是迄今为止尚未满足的主要需求。最后,新的策略,特别是抗- xi药物,似乎是有吸引力的选择,目前正在评估治疗与癌症相关的血栓。总结:癌症相关血栓患者预后的改善伴随着新的治疗策略,以提高这些脆弱的患者抗凝治疗的获益-风险比,这些患者既有静脉血栓栓塞复发的风险,也有出血并发症的风险。
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来源期刊
Current Opinion in Oncology
Current Opinion in Oncology 医学-肿瘤学
CiteScore
6.10
自引率
2.90%
发文量
130
审稿时长
4-8 weeks
期刊介绍: With its easy-to-digest reviews on important advances in world literature, Current Opinion in Oncology offers expert evaluation on a wide range of topics from sixteen key disciplines including sarcomas, cancer biology, melanoma and endocrine tumors. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by annotated references detailing the merits of the most important papers.
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