Chemical Constituents of the Deep-Sea-Derived Fungus Trichoderma simmonsii ZEN3.

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-01-25 DOI:10.1002/cbdv.202500135

Yun-Fei Song, Yuan Wang, Zheng-Biao Zou, Rong Chao, Tai-Zong Wu, Tian-Hua Zhong, A-Long Zhang, Cheng-Hai Gao, Xian-Wen Yang

引用次数: 0

Abstract

Two new nor-rubrofusarin derivatives (trichsimins A and B, 1 and 2) and one new chromone derivative (trichsimin C, 5) were isolated from the deep-sea-derived Trichoderma simmonsii ZEN3 along with 20 known compounds (3, 4, and 6-23). The structures of the new compounds were established by detailed analyses of the NMR, HRESIMS, and optical rotatory dispersion (ORD) data. Nafuredin (14) exhibited potent inhibition against RSL3-induced ferroptosis with an EC₅₀ value of 5.54 µM.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.