Sensory Symptoms as an Early Manifestation of Active Vitiligo: A Case–Control Clinical and Molecular Study

IF 2.6 3区 医学 Q2 CELL BIOLOGY
Hagar El Sayed, Hala El Wakeel, Zeinab Nour, Riham Mohyeeldeen, Vanessa Hafez
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引用次数: 0

Abstract

Vitiligo pathogenesis is complex. There is some evidence in support of the neurohormonal pathways involved. Although considered a nonpruritic condition, some patients may experience itching, which can occur ahead of the appearance of the patches. We aimed to assess sensory symptoms in active and stable vitiligo patients and to measure 3 neuropeptide expressions in their lesional skin (neuropeptide Y [NPY], calcitonin gene–related peptide [CGRP], and nerve growth factors [NGF]) to correlate neuropeptide levels and sensory symptoms, with vitiligo activity. This case–control study included 85 patients, aged 18 years and older, analyzed into active or stable vitiligo groups. Patients were screened for itching or other abnormal neurological sensations such as paresthesia and numbness. The Vitiligo Disease Activity Score, Vitiligo Signs of Activity Score, and dermoscopic score were performed to assess disease activity. Three neuropeptides were quantified by enzyme-linked immunosorbent assay in skin biopsies from the edge of vitiligo lesions. A normal control group was also included. Results showed that 24.7% of patients had sensory symptoms: itching (18.8%), paresthesia (2.4%), and numbness (3.5%). The NGF, CGRP, and NPY levels were significantly higher in skin of normal controls compared to stable and active vitiligo patients. They were lowest in active vitiligo skin (p = 0.001, 0.016, and 0.01, respectively). NGF was the most relevant neuropeptide to vitiligo activity and sensory manifestations. In conclusion, almost one-third of the patients with active vitiligo reported sensory symptoms, predominantly itching, thus sensory manifestations may suggest a prodroma of activity and could be included in the screening tools for vitiligo activity.

Trial Registration: www.clinicaltrials.gov (NCT05390164).

感觉症状是活动性白癜风的早期表现:病例对照临床和分子研究。
白癜风发病机制复杂。有一些证据支持其中涉及的神经激素途径。虽然被认为是一种非瘙痒性的情况,但一些患者可能会感到瘙痒,这可能发生在斑块出现之前。我们旨在评估活动性和稳定性白癜风患者的感觉症状,并测量病变皮肤中3种神经肽(神经肽Y [NPY]、降钙素基因相关肽[CGRP]和神经生长因子[NGF])的表达,以将神经肽水平和感觉症状与白癜风活动联系起来。本病例对照研究纳入85例年龄在18岁及以上的白癜风患者,分为活动性白癜风组和稳定性白癜风组。对患者进行瘙痒或其他异常神经感觉(如感觉异常和麻木)的筛查。白癜风疾病活动性评分、白癜风活动体征评分和皮肤镜评分用于评估疾病活动性。在白癜风病变边缘的皮肤活检中,用酶联免疫吸附法定量测定了三种神经肽。另设正常对照组。结果24.7%的患者有感觉症状:瘙痒(18.8%)、感觉异常(2.4%)、麻木(3.5%)。与稳定型和活动性白癜风患者相比,正常对照皮肤的NGF、CGRP和NPY水平明显更高。活动性白癜风皮肤最低(p分别为0.001、0.016和0.01)。NGF是与白癜风活动和感觉表现最相关的神经肽。总之,几乎三分之一的活动性白癜风患者报告感觉症状,主要是瘙痒,因此感觉表现可能提示活动前驱,可以纳入白癜风活动性筛查工具。试验注册:www.clinicaltrials.gov (NCT05390164)。
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来源期刊
Pigment Cell & Melanoma Research
Pigment Cell & Melanoma Research 医学-皮肤病学
CiteScore
8.90
自引率
2.30%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Pigment Cell & Melanoma Researchpublishes manuscripts on all aspects of pigment cells including development, cell and molecular biology, genetics, diseases of pigment cells including melanoma. Papers that provide insights into the causes and progression of melanoma including the process of metastasis and invasion, proliferation, senescence, apoptosis or gene regulation are especially welcome, as are papers that use the melanocyte system to answer questions of general biological relevance. Papers that are purely descriptive or make only minor advances to our knowledge of pigment cells or melanoma in particular are not suitable for this journal. Keywords Pigment Cell & Melanoma Research, cell biology, melatonin, biochemistry, chemistry, comparative biology, dermatology, developmental biology, genetics, hormones, intracellular signalling, melanoma, molecular biology, ocular and extracutaneous melanin, pharmacology, photobiology, physics, pigmentary disorders
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