Supramolecular Chemistry Empowers Vat Photopolymerization Mediated DLP-3D Printing of PVA-MA-AA Resin for pH-Responsive Drug Delivery Applications

IF 7.2 2区材料科学 Q2 CHEMISTRY, PHYSICAL

Chemistry of Materials Pub Date : 2025-01-27 DOI:10.1021/acs.chemmater.4c02802

Harshada Satpute, Purushottam Suryavanshi, Subham Banerjee

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引用次数: 0

Abstract

Vat photopolymerization (VP) offers exceptional precision by carefully directing light to materials that can be cross-linked or photopolymerized via photosensitive reactions. However, traditional photo-cross-linking forms a dense network that hinders the drug release. To overcome this, supramolecular interactions between photopolymer chains can be used instead of dense covalent bonding to achieve reversible noncovalent bonding. In this study, we introduce a photocurable resin through supramolecular chemistry empowered VP mediated DLP-3DP that can fabricate solid structures, provide a versatile release profile, and overcome the limitations of DLP 3D printing in personalized drug delivery systems. Supramolecular interactions between poly(vinyl alcohol)-methacrylate (PVA-MA) and acrylic acid (AA) were used to produce photocurable resins and DLP-mediated acetaminophen-loaded prototypes. ¹H NMR and FT-ATR analyses confirmed the successful integration of PVA-MA and AA into the photopolymer. Furthermore, acetaminophen-loaded prototypes were thoroughly investigated for solid-state characterization, drug content analysis, and in vitro release studies. Drug content analysis confirmed each 3D-printed prototype contains 0.42 ± 0.010% w/v of acetaminophen. In vitro, release studies showed pH-dependent release behavior of acetaminophen, reaching approximately 30 and 65% within 24.0 h in acidic and basic media, respectively. The findings of the current study highlight the widespread application of DLP-3D printing in creating patient-centric and stimuli-responsive solid oral dosage forms.

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来源期刊

Chemistry of Materials 工程技术-材料科学：综合

CiteScore

14.10

自引率

5.80%

发文量

929

审稿时长

1.5 months

期刊介绍： The journal Chemistry of Materials focuses on publishing original research at the intersection of materials science and chemistry. The studies published in the journal involve chemistry as a prominent component and explore topics such as the design, synthesis, characterization, processing, understanding, and application of functional or potentially functional materials. The journal covers various areas of interest, including inorganic and organic solid-state chemistry, nanomaterials, biomaterials, thin films and polymers, and composite/hybrid materials. The journal particularly seeks papers that highlight the creation or development of innovative materials with novel optical, electrical, magnetic, catalytic, or mechanical properties. It is essential that manuscripts on these topics have a primary focus on the chemistry of materials and represent a significant advancement compared to prior research. Before external reviews are sought, submitted manuscripts undergo a review process by a minimum of two editors to ensure their appropriateness for the journal and the presence of sufficient evidence of a significant advance that will be of broad interest to the materials chemistry community.