Association between multimorbidity and the risk of dementia: A systematic review and meta-analysis

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2025-01-14 DOI:10.1016/j.archger.2025.105760

Bo Xin , Di Zhang , Hong Fu , Wenhui Jiang

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引用次数: 0

Abstract

Background

Multimorbidity has become increasingly prevalent and poses challenges in managing cognitive function. This study aimed to (1) systematically review and perform a meta-analysis to understand the relationship between multimorbidity and the risk of dementia and (2) examine the impact of different multimorbidity patterns on this relationship.

Method

A systematic review was conducted using PubMed, Embase, PsychINFO, CINAHL, and Cochrane Central to gather studies published up to December 16, 2023. For the meta-analysis, studies with consistent study designs, multimorbidity definitions, and stages of dementia were included. Heterogeneity was assessed using the I² statistic, and Egger's and Begg's tests were used to evaluate publication bias.

Results

Of the 12,074 studies identified, 11 were deemed suitable for systematic review, and eight were included in the meta-analysis. Meta-analysis of the longitudinal studies revealed that baseline multimorbidity was significantly associated with an increased risk of dementia compared with individuals without multimorbidity (HR: 1.34, 95 % CI: 1.08–1.68). Meta-analysis of the cross-sectional studies indicated that multimorbidity was significantly associated with a higher risk of being in the prodromal stages of dementia than in individuals without multimorbidity (OR: 1.32, 95 % CI: 1.16–1.51). The risk of dementia varied according to diverse multimorbidity patterns, and the cardiovascular-metabolic condition-related patterns were the most common and associated with high dementia risk.

Conclusions

Our findings provide quantitative evidence of a significant association between multimorbidity and the risk of dementia. To develop effective dementia prevention strategies, an in-depth understanding of specific multimorbidity patterns is invaluable for managing cognitive function.

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多病与痴呆风险之间的关系：一项系统综述和荟萃分析。

背景：多病越来越普遍，对认知功能的管理提出了挑战。本研究旨在(1)系统回顾并进行荟萃分析，以了解多发病与痴呆风险之间的关系；(2)检验不同多发病模式对这种关系的影响。方法：通过PubMed、Embase、PsychINFO、CINAHL和Cochrane Central进行系统综述，收集截至2023年12月16日发表的研究。荟萃分析纳入了具有一致研究设计、多病定义和痴呆分期的研究。异质性采用I2统计量评估，Egger’s和Begg’s检验评估发表偏倚。结果：在鉴定的12074项研究中，11项被认为适合进行系统评价，8项被纳入meta分析。纵向研究的荟萃分析显示，与没有多重发病的个体相比，基线多重发病与痴呆风险增加显著相关（HR: 1.34, 95% CI: 1.08-1.68）。横断面研究的荟萃分析表明，与没有多重发病的个体相比，多重发病与痴呆前驱期的风险显著相关（OR: 1.32, 95% CI: 1.16-1.51）。痴呆的风险根据不同的多病模式而变化，心血管代谢疾病相关模式是最常见的，与高痴呆风险相关。结论：我们的研究结果为多重发病与痴呆风险之间的显著关联提供了定量证据。为了制定有效的痴呆症预防策略，深入了解特定的多病模式对于管理认知功能是非常宝贵的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.