{"title":"Hemangiomatous ameloblastoma; A separate entity?\"","authors":"Roshna Sankar, Sharon John, Priya Devi, Saloni Verma, Priyanka Singh, Shalini Gupta","doi":"10.1053/j.semdp.2025.01.003","DOIUrl":null,"url":null,"abstract":"<p><p>Ameloblastomas (AM) are locally aggressive tumors, with hemangiomatous ameloblastoma (HA) being a rare subtype characterized by vascular proliferation, predominantly in the stroma but occasionally within the epithelial component. We report a case of a 32-year-old male with recurrent mandibular swelling, histopathologically diagnosed as unicystic HA, showing vascularity in both stroma and odontogenic epithelial islands with GLUT1 positivity in the latter. A review of 31 cases revealed a male predilection, mandibular dominance (89.74 %), and overlap with conventional AM features. Vascularity in HA is attributed to reactive, neoplastic, or angiogenic mechanisms, with rare epithelial involvement suggesting aberrant angiogenesis or vascular mimicry. Further research is essential to clarify its pathogenesis and clinical implications.</p>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Diagnostic Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1053/j.semdp.2025.01.003","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Ameloblastomas (AM) are locally aggressive tumors, with hemangiomatous ameloblastoma (HA) being a rare subtype characterized by vascular proliferation, predominantly in the stroma but occasionally within the epithelial component. We report a case of a 32-year-old male with recurrent mandibular swelling, histopathologically diagnosed as unicystic HA, showing vascularity in both stroma and odontogenic epithelial islands with GLUT1 positivity in the latter. A review of 31 cases revealed a male predilection, mandibular dominance (89.74 %), and overlap with conventional AM features. Vascularity in HA is attributed to reactive, neoplastic, or angiogenic mechanisms, with rare epithelial involvement suggesting aberrant angiogenesis or vascular mimicry. Further research is essential to clarify its pathogenesis and clinical implications.
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Each issue of Seminars in Diagnostic Pathology offers current, authoritative reviews of topics in diagnostic anatomic pathology. The Seminars is of interest to pathologists, clinical investigators and physicians in practice.
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