Demystifying the role of MMP9 and TIMP-1 as markers of lung imaging and functional abnormality of COVID-19.

IF 1.4 4区医学 Q4 INFECTIOUS DISEASES

Journal of Infection in Developing Countries Pub Date : 2024-12-31 DOI:10.3855/jidc.19929

Alfian N Rosyid, Arina D Puspitasari, Anggraini D Sensusiati, Jusak Nugraha, Muhammad Amin

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引用次数: 0

Abstract

Introduction: This study aimed to analyze the levels of MMP-9 and TIMP-1 as biomarkers for identifying lung anatomical and functional abnormalities in coronavirus disease 2019 (COVID-19).

Methodology: Adult COVID-19 patients hospitalized between October and December 2021 were included in the study. MMP-9 and TIMP-1 levels were measured from the blood. Chest X-ray was categorized using the Brixia index. A blood gas analysis was performed in the emergency room.

Results: MMP-9 was higher in severe COVID-19 patients (1,430.09 ± 1,492.22) than in non-severe cases (819.90 ± 750.13) with p < 0.05, but not different between mortality groups. TIMP-1 was lower in non-severe cases (4.88 ± 3.49) than in severe cases (8.61 ± 9.09) with p > 0.05. The increase in MMP-9 was correlated to TIMP-1 with a linear regression value R2 = 0.945. Lung abnormalities were categorized as normal (6.9%), mild (23.6%), moderate (29.2%), and severe (40.3%). Brixia score was significantly correlated with FiO2 (r = 0.547), PaO2/FiO2 (r = - 0.317), and SpO2/FiO2 (r = - 0.476). MMP-9 and TIMP-1 were significantly correlated with the Brixia score (r = 0.315 and r = - 0.234, respectively), and PaO2/FiO2 (r = - 0.291 and r = 0.283, respectively). MMP-9 was significantly correlated with severity (r = 0.313).

Conclusion: MMP-9 and TIMP-1 were related to lung imaging, functional abnormalities, and severity; but were not associated with mortality.

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来源期刊

Journal of Infection in Developing Countries INFECTIOUS DISEASES-

CiteScore

3.70

自引率

5.30%

发文量

239

审稿时长

4-8 weeks

期刊介绍： The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.