Absolute eosinophil count and expression analyses of cytokine genes in Haemonchus contortus resistant Malpura sheep: Role of TH1/TH2 cytokine dichotomy

IF 1.4 Q3 PARASITOLOGY

Veterinary parasitology, regional studies and reports Pub Date : 2025-01-01 DOI:10.1016/j.vprsr.2025.101194

Rajiv Kumar , Amar S. Meena , Chander P. Swarnkar , Siddharth S. Misra , Arun Kumar

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引用次数: 0

Abstract

A strong Th2-type immune response against Haemonchus contortus infection in genetically resistant sheep provide immunity. The objective of present study was to correlate mean faecal egg counts (FECs), absolute eosinophil counts and Th1/Th2 gene expression in resistant (R) and susceptible (S) Malpura sheep. In spite of no anthelmintic treatment in R line, on majority of the months, mean FECs remained significantly (P < 0.05) lower compared to S line where anthelmintic treatment was given in September every year. R sheep possess a smaller number of blood eosinophils in the majority of months as compared with S sheep and a positive correlation has been observed between absolute eosinophil counts and mean FEC. In the condition, when FEC remain similar in both the lines (R and S), significantly (P < 0.05) up-regulated expression of IL-5 was observed in R sheep compared with S sheep however when FEC is hugely enhanced; IL-2, IL-6, IL-12 and IL-13 gene expression was significantly (P < 0.05) up-regulated in R sheep as compared to S sheep which is dependent on season and parasite load.

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嗜酸性粒细胞绝对数和细胞因子基因的表达分析：TH1/TH2 细胞因子二分法的作用。

具有遗传抗性的绵羊对弯曲血蜱感染产生强烈的th2型免疫反应，从而提供免疫力。本研究的目的是研究耐药(R)和易感(S)马尔普拉羊的平均粪卵计数（FECs）、绝对嗜酸性粒细胞计数和Th1/Th2基因表达的相关性。尽管在R系没有驱虫处理，但在大多数月份，平均FECs仍然显著(P

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary parasitology, regional studies and reports Multiple-

CiteScore

2.90

自引率

7.10%

发文量

126

审稿时长

97 days

期刊介绍： Veterinary Parasitology: Regional Studies and Reports focuses on aspects of veterinary parasitology that are of regional concern, which is especially important in this era of climate change and the rapid and often unconstrained travel of people and animals. Relative to regions, this journal will accept papers of the highest quality dealing with all aspects of disease prevention, pathology, treatment, epidemiology, and control of parasites within the field of veterinary medicine. Also, case reports will be considered as they add to information related to local disease and its control; such papers must be concise and represent appropriate medical intervention. Papers on veterinary parasitology from wildlife species are acceptable, but only if they relate to the practice of veterinary medicine. Studies on vector-borne bacterial and viral agents are suitable, but only if the paper deals with vector transmission of these organisms to domesticated animals. Studies dealing with parasite control by means of natural products, both in vivo and in vitro, are more suited for one of the many journals that now specialize in papers of this type. However, due to the regional nature of much of this research, submissions may be considered based upon a case being made by the author(s) to the Editor. Circumstances relating to animal experimentation must meet the International Guiding Principles for Biomedical Research Involving Animals as issued by the Council for International Organizations of Medical Sciences (obtainable from: Executive Secretary C.I.O.M.S., c/o W.H.O., Via Appia, CH-1211 Geneva 27, Switzerland).