Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes.

IF 6.5 2区医学 Q1 ONCOLOGY

NPJ Breast Cancer Pub Date : 2025-01-24 DOI:10.1038/s41523-025-00719-w

Fresia Pareja, Rohit Bhargava, Virginia F Borges, Edi Brogi, Rita Canas Marques, Fatima Cardoso, Christine Desmedt, Malini Harigopal, Sunil R Lakhani, Adrian Lee, Jose Pablo Leone, Hannah Linden, Christopher J Lord, Caterina Marchio, Sofia D Merajver, Emad Rakha, Jorge S Reis-Filho, Andrea Richardson, Elinor Sawyer, Pepper Schedin, Christopher J Schwartz, Andrew Tutt, Naoto T Ueno, Anne Vincent-Salomon, Britta Weigelt, Y Hannah Wen, Stuart J Schnitt, Steffi Oesterreich

引用次数: 0

Abstract

Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges. Emerging therapeutic strategies targeting genetic alterations or immune microenvironment are being explored.

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来源期刊

NPJ Breast Cancer Medicine-Pharmacology (medical)

CiteScore

10.10

自引率

1.70%

发文量

122

审稿时长

9 weeks

期刊介绍： npj Breast Cancer publishes original research articles, reviews, brief correspondence, meeting reports, editorial summaries and hypothesis generating observations which could be unexplained or preliminary findings from experiments, novel ideas, or the framing of new questions that need to be solved. Featured topics of the journal include imaging, immunotherapy, molecular classification of disease, mechanism-based therapies largely targeting signal transduction pathways, carcinogenesis including hereditary susceptibility and molecular epidemiology, survivorship issues including long-term toxicities of treatment and secondary neoplasm occurrence, the biophysics of cancer, mechanisms of metastasis and their perturbation, and studies of the tumor microenvironment.