Causal association among smoking, bitter beverage consumption, and risk of osteoporosis: a two-sample mendelian randomization-based study.

IF 2.7 3区 生物学
Yanqian Wu, Jianqian Chao, Min Bao, Na Zhang, Leixia Wang
{"title":"Causal association among smoking, bitter beverage consumption, and risk of osteoporosis: a two-sample mendelian randomization-based study.","authors":"Yanqian Wu, Jianqian Chao, Min Bao, Na Zhang, Leixia Wang","doi":"10.1186/s41065-025-00371-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Two-sample MR methods were employed to analyze the impact of smoking and bitter beverage consumption on the risk of osteoporosis and osteoporosis with pathological fractures, in order to assess the causal association.</p><p><strong>Methods: </strong>Publicly available genome-wide association study summary data were analyzed using MR methods. The exposures investigated were smoking (smoking per day, smoking initiation, and lifetime smoking index) and bitter beverages (coffee, tea, bitter alcoholic beverages, bitter non-alcoholic beverages, and total bitter beverages). The outcomes examined were the risk of osteoporosis and osteoporosis with pathological fractures. The inverse-variance weighted (IVW) method was used as the main statistical model. The stability and reliability of the results were verified by the Cochran's Q test, the Egger-intercept test, and the leave-one-out analysis.</p><p><strong>Results: </strong>Smoking per day was causally associated with the risk of osteoporosis OR = 1.417, 95% CI = 1.119-1.794, P = 0.003), and lifetime smoking index had a possible genetic causal association with the risk of osteoporosis with pathological fractures (OR = 4.187, 95% CI = 1.909-9.184, P < 0.001). No genetic causal association was found between smoking initiation or lifetime smoking index and the risk of osteoporosis (P > 0.05). No genetic causal association was identified between smoking per day or smoking initiation and the risk of osteoporosis with pathological fractures (P > 0.05). Total and bitter non-alcoholic beverage consumption showed a potential effect on the risk of osteoporosis (OR = 3.687, 95% CI = 1.535-8.858, P = 0.003 and OR = 3.040, 95% CI = 1.466-6.304, P = 0.002, respectively).</p><p><strong>Conclusions: </strong>This study found smoking raises the risk of osteoporosis and osteoporosis with pathological fractures based on genetics. Certain bitter beverages are linked to an increased osteoporosis risk.</p>","PeriodicalId":12862,"journal":{"name":"Hereditas","volume":"162 1","pages":"7"},"PeriodicalIF":2.7000,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760116/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hereditas","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1186/s41065-025-00371-1","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives: Two-sample MR methods were employed to analyze the impact of smoking and bitter beverage consumption on the risk of osteoporosis and osteoporosis with pathological fractures, in order to assess the causal association.

Methods: Publicly available genome-wide association study summary data were analyzed using MR methods. The exposures investigated were smoking (smoking per day, smoking initiation, and lifetime smoking index) and bitter beverages (coffee, tea, bitter alcoholic beverages, bitter non-alcoholic beverages, and total bitter beverages). The outcomes examined were the risk of osteoporosis and osteoporosis with pathological fractures. The inverse-variance weighted (IVW) method was used as the main statistical model. The stability and reliability of the results were verified by the Cochran's Q test, the Egger-intercept test, and the leave-one-out analysis.

Results: Smoking per day was causally associated with the risk of osteoporosis OR = 1.417, 95% CI = 1.119-1.794, P = 0.003), and lifetime smoking index had a possible genetic causal association with the risk of osteoporosis with pathological fractures (OR = 4.187, 95% CI = 1.909-9.184, P < 0.001). No genetic causal association was found between smoking initiation or lifetime smoking index and the risk of osteoporosis (P > 0.05). No genetic causal association was identified between smoking per day or smoking initiation and the risk of osteoporosis with pathological fractures (P > 0.05). Total and bitter non-alcoholic beverage consumption showed a potential effect on the risk of osteoporosis (OR = 3.687, 95% CI = 1.535-8.858, P = 0.003 and OR = 3.040, 95% CI = 1.466-6.304, P = 0.002, respectively).

Conclusions: This study found smoking raises the risk of osteoporosis and osteoporosis with pathological fractures based on genetics. Certain bitter beverages are linked to an increased osteoporosis risk.

吸烟、饮用苦味饮料和骨质疏松风险之间的因果关系:一项基于孟德尔随机的双样本研究。
目的:采用双样本MR方法分析吸烟和饮用苦饮料对骨质疏松和骨质疏松合并病理性骨折风险的影响,以评估两者之间的因果关系。方法:使用MR方法分析公开的全基因组关联研究汇总数据。所调查的暴露是吸烟(每天吸烟、开始吸烟和终生吸烟指数)和苦味饮料(咖啡、茶、苦味酒精饮料、苦味非酒精饮料和全苦味饮料)。研究结果为骨质疏松和骨质疏松合并病理性骨折的风险。采用反方差加权法(IVW)作为主要统计模型。通过Cochran’s Q检验、egg -intercept检验和leave- out分析验证了结果的稳定性和可靠性。结果:每日吸烟与骨质疏松发生风险呈正相关(OR = 1.417, 95% CI = 1.119 ~ 1.794, P = 0.003),终生吸烟指数与骨质疏松合并病理性骨折发生风险呈正相关(OR = 4.187, 95% CI = 1.909 ~ 9.184, P 0.05)。每天吸烟或开始吸烟与骨质疏松合并病理性骨折的风险之间没有遗传因果关系(P < 0.05)。总饮用量和苦味非酒精饮料对骨质疏松症风险有潜在影响(OR = 3.687, 95% CI = 1.535-8.858, P = 0.003; OR = 3.040, 95% CI = 1.466-6.304, P = 0.002)。结论:本研究发现吸烟增加骨质疏松症和骨质疏松症伴病理性骨折的遗传学风险。某些苦味饮料会增加患骨质疏松症的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Hereditas
Hereditas Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
3.80
自引率
3.70%
发文量
0
期刊介绍: For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信