Genome-wide association analysis of composite sleep health scores in 413,904 individuals.

IF 5.2 1区生物学 Q1 BIOLOGY

Communications Biology Pub Date : 2025-01-24 DOI:10.1038/s42003-025-07514-0

Matthew O Goodman, Tariq Faquih, Valentina Paz, Pavithra Nagarajan, Jacqueline M Lane, Brian Spitzer, Matthew Maher, Joon Chung, Brian E Cade, Shaun M Purcell, Xiaofeng Zhu, Raymond Noordam, Andrew J K Phillips, Simon D Kyle, Kai Spiegelhalder, Michael N Weedon, Deborah A Lawlor, Jerome I Rotter, Kent D Taylor, Carmen R Isasi, Tamar Sofer, Hassan S Dashti, Martin K Rutter, Susan Redline, Richa Saxena, Heming Wang

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引用次数: 0

Abstract

Recent genome-wide association studies (GWASs) of several individual sleep traits have identified hundreds of genetic loci, suggesting diverse mechanisms. Moreover, sleep traits are moderately correlated, so together may provide a more complete picture of sleep health, while illuminating distinct domains. Here we construct novel sleep health scores (SHSs) incorporating five core self-report measures: sleep duration, insomnia symptoms, chronotype, snoring, and daytime sleepiness, using additive (SHS-ADD) and five principal components-based (SHS-PCs) approaches. GWASs of these six SHSs identify 28 significant novel loci adjusting for multiple testing on six traits (p < 8.3e-9), along with 341 previously reported loci (p < 5e-08). The heritability of the first three SHS-PCs equals or exceeds that of SHS-ADD (SNP-h² = 0.094), while revealing sleep-domain-specific genetic discoveries. Significant loci enrich in multiple brain tissues and in metabolic and neuronal pathways. Post-GWAS analyses uncover novel genetic mechanisms underlying sleep health and reveal connections (including potential causal links) to behavioral, psychological, and cardiometabolic traits.

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来源期刊

Communications Biology Medicine-Medicine (miscellaneous)

CiteScore

8.60

自引率

1.70%

发文量

1233

审稿时长

13 weeks

期刊介绍： Communications Biology is an open access journal from Nature Research publishing high-quality research, reviews and commentary in all areas of the biological sciences. Research papers published by the journal represent significant advances bringing new biological insight to a specialized area of research.