Aromatic Polyketides From a Marine-Derived Streptomyces Species.

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-01-24 DOI:10.1002/cbdv.202500129

Jingjing Shen, Shan Cheng, Zhi Liu, Weiming Zhu, Peng Fu

引用次数: 0

Abstract

Three new naphthalene derivatives, strepthalenes A-C (1-3), and the known analogue (S)-DNPA (4), together with six previously reported anthraquinones (5-10), were isolated from the marine-derived Streptomyces sp. OUCMDZ-4182. Their structures were elucidated by detailed spectroscopic analysis and quantum chemical calculations. Strepthalenes B and C showed moderate activity against amyloid-β 42 (Aβ42) aggregation with IC₅₀ values of 47.65 and 24.73 µM, respectively.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.