Trajectories of intrinsic connectivity one year post pediatric mild traumatic brain injury: Neural injury superimposed on neurodevelopment

IF 3.2 2区心理学 Q1 BEHAVIORAL SCIENCES

Cortex Pub Date : 2025-01-13 DOI:10.1016/j.cortex.2024.12.022

Harm J. van der Horn , Tracey V. Wick , Josef M. Ling , Jessica R. McQuaid , Upasana Nathaniel , Samuel D. Miller , Divyasree Sasi Kumar , Vadim Zotev , Andrei A. Vakhtin , Sephira G. Ryman , Joana Cabral , John P. Phillips , Richard A. Campbell , Robert E. Sapien , Andrew R. Mayer

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引用次数: 0

Abstract

The developing brain undergoes rapid changes throughout middle childhood and adolescence. The disambiguation of long-term changes in intrinsic activity following pediatric mild traumatic brain injury (pmTBI) from typical development can therefore only be ascertained in longitudinal studies with large sample size and at least three serial assessments. A comprehensive clinical battery and resting-state fMRI data were collected approximately 1-week (N = 263; 8-18 years old), 4-months (N = 192) and 1-year (N = 153) post-injury, with identical visits in a large cohort (N = 228) of age- and sex-matched healthy controls (HC). Results indicated persistent frontocerebellar and thalamic connectivity changes up to 1-year post-injury in pmTBI relative to controls (P's < .001), with similar longitudinal connectivity trajectories (i.e., typical neurodevelopment). Alterations in precuneal midline connectivity (p's < .05) and occupancy of a default mode/limbic dynamic brain state were present only up to 4-months (p's < .001) rather than 1-year (p's > .44) post-injury. However, absent group differences at 1-year post-injury may be explained as pseudo-normalization due to altered longitudinal connectivity trajectories in pmTBI associated with neurodevelopment. Persistent alterations of precuneal connectivity were also associated with lower executive function and long-term memory scores. In conclusion, pmTBI may result in chronic changes to both static and dynamic intrinsic connectivity which further interact with typical neurodevelopment. Longer follow-up studies may be needed to unravel this interaction.

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儿童轻度创伤性脑损伤后一年的内在连通性轨迹：神经损伤叠加在神经发育上。

发育中的大脑在童年中期和青春期经历了快速的变化。因此，儿童轻度创伤性脑损伤（pmTBI）后内在活动的长期变化与典型发展的区别只能通过大样本量的纵向研究和至少三个系列评估来确定。大约1周收集全面的临床电池和静息状态fMRI数据(N = 263；8-18岁)、4个月（N = 192）和1年（N = 153）损伤后，在年龄和性别匹配的健康对照（HC）中进行相同的访问。结果显示，相对于对照组，pmTBI损伤后1年内持续的额小脑和丘脑连通性改变（P = 0.44）。然而，在损伤后1年没有组间差异可以解释为由于与神经发育相关的pmTBI的纵向连接轨迹改变而导致的伪正常化。前额叶连通性的持续改变也与较低的执行功能和长期记忆得分有关。总之，pmTBI可能导致静态和动态内在连通性的慢性改变，并进一步与典型的神经发育相互作用。可能需要更长的后续研究来揭示这种相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cortex 医学-行为科学

CiteScore

7.00

自引率

5.60%

发文量

250

审稿时长

74 days

期刊介绍： CORTEX is an international journal devoted to the study of cognition and of the relationship between the nervous system and mental processes, particularly as these are reflected in the behaviour of patients with acquired brain lesions, normal volunteers, children with typical and atypical development, and in the activation of brain regions and systems as recorded by functional neuroimaging techniques. It was founded in 1964 by Ennio De Renzi.