Comparison of Vessel Responses Following Combined Sirolimus-Eluting and Endothelial Progenitor Cell Stent and Ultra-Thin Sirolimus-Eluting Stent Implantation by Serial Optical Coherence Tomography and Coronary Angioscopy: A Multicenter Observational Study

IF 2.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

American Journal of Cardiology Pub Date : 2025-01-23 DOI:10.1016/j.amjcard.2025.01.009

Daisuke Nakamura MD , Isamu Mizote MD, PhD , Takayuki Ishihara MD , Yutaka Matsuhiro MD , Shota Okuno MD, PhD , Tatsuya Shiraki MD , Takuya Tsujimura MD , Naotaka Okamoto MD , Naoki Itaya MD , Takaharu Nakayoshi MD , Atsushi Kikuchi MD , Tsutomu Kawai MD , Yuhei Nojima MD, PhD , Mitsuyoshi Takahara MD, PhD , Takashi Morita MD, PhD , Shungo Hikosou MD, PhD , Daisaku Nakatani MD, PhD , Toshiaki Mano MD, PhD , Takahisa Yamada MD, PhD , Takahumi Ueno MD, PhD , Yasushi Sakata MD, PhD

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引用次数: 0

Abstract

A dual-therapy sirolimus-eluting and CD34+ antibody–coated Combo Stent (DTS) has been developed to enhance endothelization and capture endothelial progenitor cells; however, vessel responses following DTS implantation remain unclear. Therefore, we evaluated early- and mid-term intravascular characteristics of DTS using intravascular imaging modalities. This multicenter, prospective, observational study enrolled 88 patients (95 lesions) who underwent DTS (43 patients, 48 lesions) or sirolimus-eluting Orsiro stent (SES, 45 patients, 47 lesions) implantation. Serial optical coherence tomography (OCT) and coronary angioscopy (CAS) findings were compared between the groups at 1 and 12 months.The OCT findings were similar between the DTS and SES groups at 1 month, including the covered strut rate (84.21 ± 9.50% versus 80.56 ± 17.68%, p = 0.27). CAS findings were also comparable despite a more severe yellow coloration observed in the DTS group (p = 0.006). At 12 months, OCT findings revealed that the covered and adequate strut coverage (≥40 μm) rates were significantly higher (99.27 ± 0.95% versus 95.46 ± 5.56%, p <0.001 and 88.90 ± 10.15% versus 72.96 ± 16.48%, p <0.001) and neointimal thickness was significantly thicker (152.16 ± 70.31 versus 84.39 ± 29.80 μm, p <0.001) in DTS than in SES. The malapposed strut rate was significantly higher in SES than in DTS (0.04 ± 0.18% versus 0.82 ± 1.87%, p = 0.018). CAS revealed that the yellow coloration (p = 0.049) and subclinical intrastent thrombus (p = 0.019) were less severe in DTS than in SES at 12 months. In conclusion, DTS provided better advantages regarding strut coverage and plaque stabilization compared to SES. However, given the observational nature of this study, further randomized controlled trials are needed to confirm these findings.

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通过连续光学相干断层扫描和冠状动脉血管造影比较联合西罗莫司洗脱和内皮祖细胞支架与超薄西罗莫司洗脱支架植入后的血管反应：一项多中心观察研究。

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来源期刊

American Journal of Cardiology 医学-心血管系统

CiteScore

4.00

自引率

3.60%

发文量

698

审稿时长

33 days

期刊介绍： Published 24 times a year, The American Journal of Cardiology® is an independent journal designed for cardiovascular disease specialists and internists with a subspecialty in cardiology throughout the world. AJC is an independent, scientific, peer-reviewed journal of original articles that focus on the practical, clinical approach to the diagnosis and treatment of cardiovascular disease. AJC has one of the fastest acceptance to publication times in Cardiology. Features report on systemic hypertension, methodology, drugs, pacing, arrhythmia, preventive cardiology, congestive heart failure, valvular heart disease, congenital heart disease, and cardiomyopathy. Also included are editorials, readers'' comments, and symposia.