Risk of clinically significant prostate cancer undercategorized by multiparametric magnetic resonance imaging.

IF 2.3 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Abdominal Radiology Pub Date : 2025-01-25 DOI:10.1007/s00261-024-04792-w

Wangshu Zhu, Haining Long, Weibin Yu, Yijia Xiong, Caixia Fu, Jungong Zhao, Xiaohong Liu

{"title":"Risk of clinically significant prostate cancer undercategorized by multiparametric magnetic resonance imaging.","authors":"Wangshu Zhu, Haining Long, Weibin Yu, Yijia Xiong, Caixia Fu, Jungong Zhao, Xiaohong Liu","doi":"10.1007/s00261-024-04792-w","DOIUrl":null,"url":null,"abstract":"Background: To investigative potential clinicopathological characteristics and imaging-related risk factors of clinically significant prostate cancer (csPCa) undercategorized in patients with negative or equivocal MRI.Methods: This retrospective study included 581 patients with pathologically confirmed csPCa (Gleason score ≥ 3 + 4), including 108 undercategorized csPCa and 473 detected csPCa. All patients underwent multiparametric MRI (mpMRI). The undercategorized csPCa was defined as a MRI result with PI-RADS ≤ 3. The clinicopathological characteristics and imaging-related factors were compared between the undercategorized group(Group A) (PI-RADS 1-3) and detected group (Group B) (PI-RADS 4-5).Results: The age, total PSA levels, PSAD, free PSA, prostate imaging quality (PI-QUAL) scores, and Gleason scores were significantly lower in the Group A than Group B. The lesions were larger and involved in peripheral and transition zones in the Group B. A significant difference in the second reading opinion. Age (odds ratio [OR], 0.94), PSAD (OR, 0.09), and PI-QUAL scores (OR, 0.25) were significantly associated with the undercategorized csPCa. The rate of undercategorized csPCa with these three risk factors (age, PSAD, and PI-QUAL scores of < 71, < 0.355, and < 3, respectively) was 68.62%. The lack of zoomed-DWI resulted in lower PI-QUAL scores. Finally, the probability of undercategorized csPCa without zoomed DWI was 3.186 times higher than that with zoomed DWI when the PSAD ratio is lower than 0.355.Conclusions: Low image quality, younger age, and lower PSAD contribute to csPCa undercategorized by mpMRI. Moreover, the use of zoomed DWI decreased undercategorized csPCa by improving PI-QUAL scores of MRI images.","PeriodicalId":7126,"journal":{"name":"Abdominal Radiology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Abdominal Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00261-024-04792-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Background: To investigative potential clinicopathological characteristics and imaging-related risk factors of clinically significant prostate cancer (csPCa) undercategorized in patients with negative or equivocal MRI.

Methods: This retrospective study included 581 patients with pathologically confirmed csPCa (Gleason score ≥ 3 + 4), including 108 undercategorized csPCa and 473 detected csPCa. All patients underwent multiparametric MRI (mpMRI). The undercategorized csPCa was defined as a MRI result with PI-RADS ≤ 3. The clinicopathological characteristics and imaging-related factors were compared between the undercategorized group(Group A) (PI-RADS 1-3) and detected group (Group B) (PI-RADS 4-5).

Results: The age, total PSA levels, PSAD, free PSA, prostate imaging quality (PI-QUAL) scores, and Gleason scores were significantly lower in the Group A than Group B. The lesions were larger and involved in peripheral and transition zones in the Group B. A significant difference in the second reading opinion. Age (odds ratio [OR], 0.94), PSAD (OR, 0.09), and PI-QUAL scores (OR, 0.25) were significantly associated with the undercategorized csPCa. The rate of undercategorized csPCa with these three risk factors (age, PSAD, and PI-QUAL scores of < 71, < 0.355, and < 3, respectively) was 68.62%. The lack of zoomed-DWI resulted in lower PI-QUAL scores. Finally, the probability of undercategorized csPCa without zoomed DWI was 3.186 times higher than that with zoomed DWI when the PSAD ratio is lower than 0.355.

Conclusions: Low image quality, younger age, and lower PSAD contribute to csPCa undercategorized by mpMRI. Moreover, the use of zoomed DWI decreased undercategorized csPCa by improving PI-QUAL scores of MRI images.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Abdominal Radiology Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

5.20

自引率

8.30%

发文量

334

期刊介绍： Abdominal Radiology seeks to meet the professional needs of the abdominal radiologist by publishing clinically pertinent original, review and practice related articles on the gastrointestinal and genitourinary tracts and abdominal interventional and radiologic procedures. Case reports are generally not accepted unless they are the first report of a new disease or condition, or part of a special solicited section. Reasons to Publish Your Article in Abdominal Radiology: · Official journal of the Society of Abdominal Radiology (SAR) · Published in Cooperation with: European Society of Gastrointestinal and Abdominal Radiology (ESGAR) European Society of Urogenital Radiology (ESUR) Asian Society of Abdominal Radiology (ASAR) · Efficient handling and Expeditious review · Author feedback is provided in a mentoring style · Global readership · Readers can earn CME credits