Optimizing Electroconvulsive Therapy With E-Field Modeling: A Narrative Review.

IF 1.8 4区医学 Q3 BEHAVIORAL SCIENCES

Journal of Ect Pub Date : 2025-01-24 DOI:10.1097/YCT.0000000000001111

Caili Ren, Simon Kung, Paul E Croarkin, Alexander Opitz, Brent P Forester, Adriana P Hermida, Martina Mueller, Sandeep R Pagali, Georgios Petrides, Stephen J Seiner, Isabel A Yoon, Maria I Lapid

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引用次数: 0

Abstract

Abstract: Electroconvulsive therapy (ECT) is an effective treatment for severe depression, especially in treatment-resistant cases. However, its potential cognitive side effects necessitate careful dosing to balance therapeutic benefits and cognitive stability. Recent advances in electric field (E-field) modeling offer promising avenues to optimize ECT dosing. This review synthesizes current knowledge on E-field modeling in ECT and explores its clinical applications. It examines the variability in E-field strengths and distributions induced by ECT and their impact on clinical outcomes. Additionally, the relationship between E-field strengths, neuroplasticity, and therapeutic efficacy is discussed. Translational studies of E-field-informed ECT are highlighted, emphasizing individualized optimal amplitude dosing and potential clinical applications. This review provides useful insights into how E-field modeling can improve the effectiveness of ECT while minimizing adverse effects, helping guide future research and clinical practice.

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利用电场模型优化电痉挛治疗：叙述性回顾。

摘要：电休克疗法（ECT）是治疗重度抑郁症的有效方法，尤其是治疗难治性抑郁症。然而，其潜在的认知副作用需要谨慎的剂量来平衡治疗效果和认知稳定性。电场（E-field）建模的最新进展为优化ECT剂量提供了有前途的途径。本文综述了电痉挛疗法中电磁场建模的最新进展，并对其临床应用进行了探讨。它检查了电痉挛引起的电场强度和分布的可变性及其对临床结果的影响。此外，还讨论了电场强度、神经可塑性和治疗效果之间的关系。强调了电子场知情ECT的转化研究，强调了个性化的最佳振幅剂量和潜在的临床应用。这篇综述提供了有用的见解，电磁场建模如何提高电痉挛治疗的有效性，同时最大限度地减少不良反应，有助于指导未来的研究和临床实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ect 医学-行为科学

CiteScore

3.70

自引率

20.00%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The Journal of ECT covers all aspects of contemporary electroconvulsive therapy, reporting on major clinical and research developments worldwide. Leading clinicians and researchers examine the effects of induced seizures on behavior and on organ systems; review important research results on the mode of induction, occurrence, and propagation of seizures; and explore the difficult sociological, ethical, and legal issues concerning the use of ECT.