Associations Between Ambient PM_2.5 and Thyroid Hormones in Pregnant Persons in Puerto Rico.

IF 3.9 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Toxics Pub Date : 2025-01-15 DOI:10.3390/toxics13010058

Trenton Honda, Trenton D Henry, Laura Corlin, Kipruto Kirwa, Akram Alshawabkeh, Julia R Varshavsky, Winston Kennedy, José F Cordero, Carmen M Velez Vega, Zaira Y Rosario Pabon, John D Meeker, Helen Suh

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引用次数: 0

Abstract

Introduction: This study investigates associations between fine particulate air pollution (PM_2.5) exposure and thyroid hormone levels during pregnancy in Puerto Rican individuals, a vulnerable population facing socioeconomic and environmental disparities.

Methods: This research draws on data from the PROTECT cohort study and involves 1040 participants to measure the effect of PM_2.5 on developmentally important thyroid hormones (TSH, T3, T4, and FT4). Pollution concentrations were linked to participant locations using EPA air quality data and analyzed across two visits during gestational weeks 16-20 and 24-28.

Results: The results suggest that PM_2.5 exposure is positively associated with maternal T3, T4, and FT4 levels but not TSH. These effects vary by timing, with T3 showing stronger associations later in pregnancy and T4/FT4 earlier. Nonlinear dose-response relationships were observed, suggesting thresholds for certain hormones.

Discussion: These findings support previous studies linking altered thyroid hormones to adverse birth outcomes and highlight the potential role of air pollution in disrupting maternal thyroid function and its implications for fetal development, calling for further research into mechanisms and interventions to mitigate these risks.

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来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.