{"title":"Syphilis in a blood bank in Argentina: Prevalence trends and risk factors.","authors":"Ana Rios Trevisan, Carolina Fernandez, Mónica Puppo, Mirta Cristina Remesar, Macarena Roel, Silvina Kuperman","doi":"10.1111/tme.13121","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Worldwide, there has been a worrying increase in the prevalence of syphilis. Blood banks have a major role in monitoring the trend of these events, despite the bias due to the altruistic donation strategy.</p><p><strong>Objectives: </strong>To determine the seroprevalence of syphilis and analyse its association with defined risk factors among blood donors at the regional blood center at Hospital Prof. Dr. J. P. Garrahan, period 2016-2022.</p><p><strong>Materials and methods: </strong>Donor screening was performed with treponemal and non-treponemal tests to determine the prevalence of active and past syphilis. Sociodemographic characteristics of donors were analysed and the association with potential risk factors was assessed.</p><p><strong>Results: </strong>A total of 72 874 donations were processed during the study period. The overall prevalence of specific anti-Treponema pallidum antibodies was 0.69% (95% CI = 0.63-0.75). Active syphilis seroprevalence was 0.30% (95% CI = 0.25-0.33). Not active syphilis seroprevalence was 0.39% (95% CI = 0.35-0.44). Anti-T. pallidum seroprevalence among first-time donations was 1.26% (95% CI = 1.14-1.38) while in repeat donations it was 0.16% (95% CI = 0.12-0.21). In univariate analysis, we found an association between syphilis and having a history of any sexually transmitted infection (OR: 5.09, 95% CI = 2.20-11.70, p < 0.01) and being first-time donors (OR: 3.48, 95% CI = 1.70-7.09, p = 0.0001).</p><p><strong>Conclusion: </strong>Although the overall prevalence of syphilis is 0.69%, among repeat donors prevalence as low as 0.16% was found. This demonstrates the need to maintain and improve screening strategies and promotion of voluntary, altruistic and repeat donation.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transfusion Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/tme.13121","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Worldwide, there has been a worrying increase in the prevalence of syphilis. Blood banks have a major role in monitoring the trend of these events, despite the bias due to the altruistic donation strategy.
Objectives: To determine the seroprevalence of syphilis and analyse its association with defined risk factors among blood donors at the regional blood center at Hospital Prof. Dr. J. P. Garrahan, period 2016-2022.
Materials and methods: Donor screening was performed with treponemal and non-treponemal tests to determine the prevalence of active and past syphilis. Sociodemographic characteristics of donors were analysed and the association with potential risk factors was assessed.
Results: A total of 72 874 donations were processed during the study period. The overall prevalence of specific anti-Treponema pallidum antibodies was 0.69% (95% CI = 0.63-0.75). Active syphilis seroprevalence was 0.30% (95% CI = 0.25-0.33). Not active syphilis seroprevalence was 0.39% (95% CI = 0.35-0.44). Anti-T. pallidum seroprevalence among first-time donations was 1.26% (95% CI = 1.14-1.38) while in repeat donations it was 0.16% (95% CI = 0.12-0.21). In univariate analysis, we found an association between syphilis and having a history of any sexually transmitted infection (OR: 5.09, 95% CI = 2.20-11.70, p < 0.01) and being first-time donors (OR: 3.48, 95% CI = 1.70-7.09, p = 0.0001).
Conclusion: Although the overall prevalence of syphilis is 0.69%, among repeat donors prevalence as low as 0.16% was found. This demonstrates the need to maintain and improve screening strategies and promotion of voluntary, altruistic and repeat donation.
背景：在世界范围内，梅毒发病率的增长令人担忧。尽管利他主义献血策略会造成偏差，但血库在监测这些事件的趋势方面发挥着重要作用：确定 2016-2022 年期间 J. P. Garrahan 教授医院地区血液中心献血者的梅毒血清阳性率，并分析其与确定风险因素的关联：通过三螺旋体和非三螺旋体检测对献血者进行筛查，以确定活动性梅毒和既往梅毒的患病率。分析了捐献者的社会人口学特征，并评估了与潜在风险因素的关联：研究期间共处理了 72 874 例捐献。特异性抗苍白螺旋体抗体的总体流行率为0.69%（95% CI = 0.63-0.75）。活动性梅毒血清阳性率为0.30%（95% CI = 0.25-0.33）。非活动梅毒血清阳性率为0.39%（95% CI = 0.35-0.44）。首次捐献者的抗苍白螺旋体血清阳性率为1.26%（95% CI = 1.14-1.38），而重复捐献者的阳性率为0.16%（95% CI = 0.12-0.21）。在单变量分析中，我们发现梅毒与任何性传播感染史之间存在关联（OR：5.09，95% CI = 2.20-11.70，P 结论：梅毒与任何性传播感染史之间存在关联（OR：5.09，95% CI = 2.20-11.70，P 结论）：虽然梅毒的总体发病率为 0.69%，但在重复捐献者中的发病率却低至 0.16%。这表明有必要保持和改进筛查策略，并推广自愿、利他和重复捐献。
期刊介绍：
Transfusion Medicine publishes articles on transfusion medicine in its widest context, including blood transfusion practice (blood procurement, pharmaceutical, clinical, scientific, computing and documentary aspects), immunohaematology, immunogenetics, histocompatibility, medico-legal applications, and related molecular biology and biotechnology.
In addition to original articles, which may include brief communications and case reports, the journal contains a regular educational section (based on invited reviews and state-of-the-art reports), technical section (including quality assurance and current practice guidelines), leading articles, letters to the editor, occasional historical articles and signed book reviews. Some lectures from Society meetings that are likely to be of general interest to readers of the Journal may be published at the discretion of the Editor and subject to the availability of space in the Journal.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
