Positive association of large alcohol intake per occasion with vision-threatening severe diabetic retinopathy or diabetic macular edema in Japanese men with type 2 diabetes

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine Pub Date : 2025-02-01 DOI:10.1016/j.ypmed.2025.108220

Masahiko Yamamoto , Kazuya Fujihara , Hiruma Hasebe , Yuta Yaguchi , Takaho Yamada , Satoru Kodama , Shiro Tanaka , Hirohito Sone

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引用次数: 0

Abstract

Objective

Differing from the overall consumption of alcohol, whether consuming large quantities of alcohol per drinking occasion is associated with higher risk of developing severe diabetic retinopathy remains unknown.

Methods

We examined whether the quantity per drinking occasion (QPO), including a large QPO, and the combinations of the frequency of alcohol consumption (FAC) and QPO were associated with higher risk of developing severe diabetic retinopathy or diabetic macular edema (DME) using adjusted Cox models. Severe diabetic retinopathy or DME was designated as a vision-threatening treatment-required diabetic eye disease (TRDED). For each man with type 2 diabetes who participated in this longitudinal retrospective cohort study, the date of the earliest health check-up during the inclusion period (April 2008 to August 2016) was set as the start date of follow-up.

Results

A TRDED was observed in 425 of 21,392 Japanese men aged 22–74 years with type 2 diabetes during a mean follow-up of 4.3 years (4.6/1000 person-years). Multivariable Cox analysis showed that a large QPO, defined as drinking three drinks or more per occasion, in low- (hazard ratio [HR], 4.76; 95 % CI, 2.06–10.97), intermediate- (HR, 1.58; 95 %CI, 1.001−2.50), and high-frequency categories (HR, 2.01; 95 % CI, 1.20–3.36) was significantly associated with elevated risks of TRDED.

Conclusions

In addition to the total amount of ethanol, these findings imply the necessity of avoiding the consumption of large amounts of alcohol on a single occasion to prevent severe diabetic retinopathy or DME.

查看原文本刊更多论文

日本男性2型糖尿病患者每次大量饮酒与威胁视力的严重糖尿病视网膜病变或糖尿病黄斑水肿呈正相关

目的：与总体饮酒不同，每次饮酒时大量饮酒是否与发生严重糖尿病视网膜病变的高风险相关尚不清楚。方法：我们使用调整后的Cox模型检查了每次饮酒次数（QPO），包括大的QPO，以及饮酒频率（FAC）和QPO的组合是否与发生严重糖尿病视网膜病变或糖尿病黄斑水肿（DME）的高风险相关。重度糖尿病视网膜病变或DME被指定为视力威胁治疗所需的糖尿病眼病（TRDED）。对于参与本纵向回顾性队列研究的每名2型糖尿病男性，将纳入期间（2008年4月至2016年8月）最早进行健康检查的日期作为随访的开始日期。结果：在平均4.3年（4.6/1000人年）的随访期间，21,392名年龄在22-74岁的日本2型糖尿病患者中有425人出现TRDED。多变量Cox分析显示，大QPO（定义为每次饮用三杯或更多）在低(风险比[HR]， 4.76；95% CI, 2.06-10.97)，中间- (HR, 1.58；95% CI, 1.001-2.50)和高频分类(HR, 2.01；95% CI, 1.20-3.36)与TRDED风险升高显著相关。结论：除了乙醇的总量外，这些发现还意味着避免在单一场合大量饮酒以预防严重的糖尿病视网膜病变或二甲醚的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Preventive medicine 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.70

自引率

3.90%

发文量

审稿时长

42 days

期刊介绍： Founded in 1972 by Ernst Wynder, Preventive Medicine is an international scholarly journal that provides prompt publication of original articles on the science and practice of disease prevention, health promotion, and public health policymaking. Preventive Medicine aims to reward innovation. It will favor insightful observational studies, thoughtful explorations of health data, unsuspected new angles for existing hypotheses, robust randomized controlled trials, and impartial systematic reviews. Preventive Medicine''s ultimate goal is to publish research that will have an impact on the work of practitioners of disease prevention and health promotion, as well as of related disciplines.