The crosstalk between exosomal miRNA and ferroptosis: A narrative review

IF 2.4 4区 生物学 Q4 CELL BIOLOGY
Zahra Nashtahosseini, Masoumeh Nejatollahi, Ahmad Fazilat, Elahe Zarif Fakoor, Alireza Emamvirdizadeh, Kamran Bahadori, Niloofar Sadat Hadian, Mohammad Valilo
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引用次数: 0

Abstract

Ferroptosis is a type of cell death that multiple mechanisms and pathways contribute to the positive and negative regulation of it. For example, increased levels of reactive oxygen species (ROS) induce ferroptosis. ferroptosis unlike apoptosis, it is not dependent on caspases, but is dependent on iron. Exosomes are membrane-bound vesicles with a size of about 30 to 150 nm, contain various cellular components, including DNA, RNA, microRNAs (miRNAs), lipids, and proteins, which are genetically similar to their cells of origin. Exosomes are found in all bodily fluids, including blood, saliva, and urine. Cells often release exosomes after their fusion with the cell membrane. They play an important role in immune regulation and cell-cell communication. miRNAs, which are noncoding RNAs with a length of about 18 to 24 nucleotides, are involved in regulating gene expression after transcription. Emerging data suggests that exosomal miRNAs are implicated in various pathophysiological mechanisms of cells, including metastasis, drug resistance, and cell death. In addition, functional studies have indicated that exosomal miRNAs can play a key role in the modulation of cell death by regulating ferroptosis. Therefore, in this review, given the importance of exosomal miRNAs in ferroptosis, we decided to elucidate the relationship between exosomal miRNAs and ferroptosis in various diseases.

Abstract Image

外泌体miRNA与铁下垂之间的串扰:一个叙述性的回顾。
铁下垂是一种多种机制和途径共同调控的细胞死亡。例如,活性氧(ROS)水平的增加会导致铁下垂。与细胞凋亡不同,铁下垂不依赖于半胱天冬酶,而是依赖于铁。外泌体是膜结合的囊泡,大小约为30 ~ 150nm,含有各种细胞成分,包括DNA、RNA、microrna (miRNAs)、脂质和蛋白质,它们与其起源细胞具有遗传相似性。外泌体存在于所有体液中,包括血液、唾液和尿液。细胞通常在与细胞膜融合后释放外泌体。它们在免疫调节和细胞间通讯中发挥重要作用。mirna是长度约为18 ~ 24个核苷酸的非编码rna,在转录后参与调控基因表达。新出现的数据表明,外泌体mirna与细胞的各种病理生理机制有关,包括转移、耐药和细胞死亡。此外,功能研究表明,外泌体mirna可以通过调节铁下垂在细胞死亡的调节中发挥关键作用。因此,在这篇综述中,考虑到外泌体miRNAs在铁下垂中的重要性,我们决定阐明外泌体miRNAs与各种疾病铁下垂之间的关系。
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来源期刊
Biology of the Cell
Biology of the Cell 生物-细胞生物学
CiteScore
5.30
自引率
0.00%
发文量
53
审稿时长
>12 weeks
期刊介绍: The journal publishes original research articles and reviews on all aspects of cellular, molecular and structural biology, developmental biology, cell physiology and evolution. It will publish articles or reviews contributing to the understanding of the elementary biochemical and biophysical principles of live matter organization from the molecular, cellular and tissues scales and organisms. This includes contributions directed towards understanding biochemical and biophysical mechanisms, structure-function relationships with respect to basic cell and tissue functions, development, development/evolution relationship, morphogenesis, stem cell biology, cell biology of disease, plant cell biology, as well as contributions directed toward understanding integrated processes at the organelles, cell and tissue levels. Contributions using approaches such as high resolution imaging, live imaging, quantitative cell biology and integrated biology; as well as those using innovative genetic and epigenetic technologies, ex-vivo tissue engineering, cellular, tissue and integrated functional analysis, and quantitative biology and modeling to demonstrate original biological principles are encouraged.
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