Iodinated Contrast Adsorption in Cartridges With Styrene-Divinylbenzene Sorbent

IF 2.2 3区医学 Q3 ENGINEERING, BIOMEDICAL

Artificial organs Pub Date : 2025-01-24 DOI:10.1111/aor.14949

Thiago Reis, Gonzalo Ramírez-Guerrero, Roberto Pecoits-Filho, Anna Lorenzin, Massimo de Cal, Valentina Corradi, Gerd Klinkmann, Federico Ronco, Francisco A. R. Neves, Rinaldo Bellomo, Claudio Ronco

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Abstract

Background

Contrast-associated acute kidney injury (CA-AKI) is frequent in patients with chronic kidney disease who are submitted to cardiac endovascular procedures using iodinated contrast. In hemoadsorption, cartridges containing styrene-divinylbenzene sorbent resin are applied to remove substances from the blood through an extracorporeal circuit. Importantly, iodinated contrast is also removed via adsorption. We aimed to determine the adsorptive kinetics of the iodinated contrast medium iohexol using a 1:3 scale model of the HA380 cartridge.

Methods

An experimental in vitro study utilizing a closed-loop extracorporeal circuit with an interposed sorbent cartridge. A solution spiked with iohexol was recirculated for 60 min. Samples for the measurement of iohexol were drawn at 0, 5, 10, 15, 20, 30, 40, and 60 min. The experiment was carried out twice.

Results

In experiments 1 and 2, the reduction ratio after 60 min was 53.0% and 53.1%, respectively. In experiment 1, iohexol clearance was 46.79 mL/min during the first 5 min and decayed to 3.57 mL/min during the last 20 min. In experiment 2, iohexol clearance was 46.72 mL/min and decayed to 3.87 mL/min during the last 20 min. The ratio of adsorbate/sorbent was 155 mg/g.

Conclusion

A 1:3 scale model of the HA380 cartridge efficiently removes iodinated contrast in a clinical-scale in vitro circuit. These findings provide a rationale for hemoadsorption as an intervention in clinical trials to prevent or attenuate CA-AKI.

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苯乙烯-二乙烯基苯吸附剂在墨盒中的碘造影剂吸附。

背景：造影剂相关急性肾损伤（CA-AKI）常见于使用碘造影剂进行心脏血管内手术的慢性肾病患者。在血液吸附中，含有苯乙烯-二乙烯基苯吸附树脂的药筒通过体外循环从血液中去除物质。重要的是，碘化造影剂也可以通过吸附去除。我们的目的是确定碘造影剂碘己醇的吸附动力学使用1:3比例模型的HA380墨盒。方法：在体外实验研究中，采用了一种内置吸附剂的闭环体外回路。加入碘己醇的溶液循环60分钟。在0、5、10、15、20、30、40、60 min抽取碘己醇测定样品。这个实验进行了两次。结果：实验1和实验2中，60 min后的还原率分别为53.0%和53.1%。在实验1中，碘己醇清除率在前5 min为46.79 mL/min，在后20 min衰减至3.57 mL/min。实验2中，碘己醇清除率为46.72 mL/min，在最后20 min衰减至3.87 mL/min。吸附剂比为155 mg/g。结论：在临床规模的体外循环中，1:3比例的HA380药盒模型有效地去除碘造影剂。这些发现为血液吸附作为临床试验预防或减轻CA-AKI的干预措施提供了理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Artificial organs 工程技术-工程：生物医学

CiteScore

4.30

自引率

12.50%

发文量

303

审稿时长

4-8 weeks

期刊介绍： Artificial Organs is the official peer reviewed journal of The International Federation for Artificial Organs (Members of the Federation are: The American Society for Artificial Internal Organs, The European Society for Artificial Organs, and The Japanese Society for Artificial Organs), The International Faculty for Artificial Organs, the International Society for Rotary Blood Pumps, The International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation. Artificial Organs publishes original research articles dealing with developments in artificial organs applications and treatment modalities and their clinical applications worldwide. Membership in the Societies listed above is not a prerequisite for publication. Articles are published without charge to the author except for color figures and excess page charges as noted.