Amirali Ghahremani, Hasan Namdar Ahmadabad, Seyed Mohammad javadzadeh, Reza shafiei
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引用次数: 0
Abstract
Pourpose
This study aimed to investigate the seroepidemiological status of Toxoplasma gondii (T. gondii) infection in Multiple Sclerosis (MS) patients compared to controls.
Methods
The present study included 98 MS patients and 100 controls. Demographic and clinical information collected through interviews, electronic medical records, and clinical examinations. Serum samples analyzed for anti-T. gondii IgG and IgM antibodies using ELISA.
Results
A significant difference observed in the seroprevalence of anti-T. gondii IgG between 49 MS patients (50%) and 33 controls (33%). MS patients with seropositive anti-T. gondii IgG had significantly different age, Expanded Disability Status Scale (EDSS) scores, MS phenotypes, age of diagnosis, and age of onset compared to seronegative patients. Serum levels of anti-T. gondii IgG significantly elevated in the case group compared to the control group (277.8 ± 28.61 vs. 137.1 ± 9.52, P < 0.0001). In controls, all subjects were seronegative for anti-T. gondii IgM; three MS cases were positive, showing no significant difference in anti-T. gondii IgM seroprevalence between groups.
Conclusion
The study suggests a potential association between T. gondii infection and MS, indicating that anti-T. gondii IgG positivity may correlate with MS phenotypes and influence disease progression. This suggests that chronic toxoplasmosis may be risk factor for MS.
期刊介绍:
Acta Parasitologica is an international journal covering the latest advances in the subject.
Acta Parasitologica publishes original papers on all aspects of parasitology and host-parasite relationships, including the latest discoveries in biochemical and molecular biology of parasites, their physiology, morphology, taxonomy and ecology, as well as original research papers on immunology, pathology, and epidemiology of parasitic diseases in the context of medical, veterinary and biological sciences. The journal also publishes short research notes, invited review articles, book reviews.
The journal was founded in 1953 as "Acta Parasitologica Polonica" by the Polish Parasitological Society and since 1954 has been published by W. Stefanski Institute of Parasitology of the Polish Academy of Sciences in Warsaw. Since 1992 in has appeared as Acta Parasitologica in four issues per year.