The Potential Role of Toxoplasma gondii Infection in Multiple Sclerosis Development: A Seroepidemiological Study in North Khorasan Province, Iran

IF 1.2 3区农林科学 Q4 PARASITOLOGY

Acta Parasitologica Pub Date : 2025-01-24 DOI:10.1007/s11686-024-00962-4

Amirali Ghahremani, Hasan Namdar Ahmadabad, Seyed Mohammad javadzadeh, Reza shafiei

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引用次数: 0

Abstract

Pourpose

This study aimed to investigate the seroepidemiological status of Toxoplasma gondii (T. gondii) infection in Multiple Sclerosis (MS) patients compared to controls.

Methods

The present study included 98 MS patients and 100 controls. Demographic and clinical information collected through interviews, electronic medical records, and clinical examinations. Serum samples analyzed for anti-T. gondii IgG and IgM antibodies using ELISA.

Results

A significant difference observed in the seroprevalence of anti-T. gondii IgG between 49 MS patients (50%) and 33 controls (33%). MS patients with seropositive anti-T. gondii IgG had significantly different age, Expanded Disability Status Scale (EDSS) scores, MS phenotypes, age of diagnosis, and age of onset compared to seronegative patients. Serum levels of anti-T. gondii IgG significantly elevated in the case group compared to the control group (277.8 ± 28.61 vs. 137.1 ± 9.52, P < 0.0001). In controls, all subjects were seronegative for anti-T. gondii IgM; three MS cases were positive, showing no significant difference in anti-T. gondii IgM seroprevalence between groups.

Conclusion

The study suggests a potential association between T. gondii infection and MS, indicating that anti-T. gondii IgG positivity may correlate with MS phenotypes and influence disease progression. This suggests that chronic toxoplasmosis may be risk factor for MS.

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刚地弓形虫感染在多发性硬化症发展中的潜在作用：伊朗北呼罗珊省的血清流行病学研究

目的：探讨多发性硬化症（MS）患者弓形虫（T. gondii）感染的血清流行病学状况。方法：本研究纳入98例MS患者和100例对照组。通过访谈、电子医疗记录和临床检查收集的人口统计和临床信息。血清样本分析抗t。ELISA法检测弓形虫IgG和IgM抗体。结果：两组血清抗t抗体阳性率有显著性差异。49例MS患者（50%）和33例对照（33%）的弓形虫IgG检测结果。MS患者血清抗t抗体阳性。与血清阴性患者相比，弓形虫IgG的年龄、扩展残疾状态量表（EDSS）评分、MS表型、诊断年龄和发病年龄均有显著差异。血清抗t抗体水平。与对照组相比，病例组弓形虫IgG明显升高（277.8±28.61∶137.1±9.52），P结论：研究提示弓形虫感染与MS存在潜在关联。弓形虫IgG阳性可能与MS表型相关并影响疾病进展。提示慢性弓形虫病可能是多发性硬化症的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Parasitologica 医学-寄生虫学

CiteScore

3.10

自引率

6.70%

发文量

149

审稿时长

6-12 weeks

期刊介绍： Acta Parasitologica is an international journal covering the latest advances in the subject. Acta Parasitologica publishes original papers on all aspects of parasitology and host-parasite relationships, including the latest discoveries in biochemical and molecular biology of parasites, their physiology, morphology, taxonomy and ecology, as well as original research papers on immunology, pathology, and epidemiology of parasitic diseases in the context of medical, veterinary and biological sciences. The journal also publishes short research notes, invited review articles, book reviews. The journal was founded in 1953 as "Acta Parasitologica Polonica" by the Polish Parasitological Society and since 1954 has been published by W. Stefanski Institute of Parasitology of the Polish Academy of Sciences in Warsaw. Since 1992 in has appeared as Acta Parasitologica in four issues per year.