Purification of crude tea tree oil through enrichment of terpinen-4-ol by in-situ formation of deep eutectic solvent

IF 8.1 1区 工程技术 Q1 ENGINEERING, CHEMICAL
Lijiao Yu , Lihong Deng , Jieyu Wu , Subhan Mahmood , Ke Yuan , Haoran Wu , Xiaodong Wang , Jing Zhang , Shun Yao
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Abstract

As a key component in tea tree oil (TTO), terpinen-4-ol exhibits ideal physiological activities. However, the high content of terpenes in crude TTO makes it challenging to enrich terpineol-4-ol. In this study, molecular simulations combined with experimental methods were used to select the optimal hydrogen bond acceptor (HBA), tetrabutylammonium chloride (TBAC), which forms a deep eutectic solvent (DES) with terpinen-4-ol in situ. Combined with necessary post-treatment process, it provided a feasible way for purification of TTO. Related DESs were prepared and characterized, and their main properties were also investigated. When the amount of TBAC was three times that of terpinen-4-ol, the formation of hydrogen bonds became more pronounced. At this point, the DES achieved its highest distribution coefficient for terpinen-4-ol (Dt = 15.02), as well as superior selectivity for terpinen-4-ol (St/c = 24.59, St/γ = 57.69). Water as the back-extractant and n-hexane as the auxiliary extractant facilitated the deep purification of terpinen-4-ol. Response surface analysis and experimental results confirmed that the optimal enrichment conditions were 30 min of enrichment time, an enrichment temperature of 60℃, and 0.5 g/g of n-hexane dosage. The back-enrichment and recovery of TBAC also proved to be satisfactory, and when applied to real tea oil, the developed method achieved over 90 % enrichment efficiency for terpinen-4-ol.
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来源期刊
Separation and Purification Technology
Separation and Purification Technology 工程技术-工程:化工
CiteScore
14.00
自引率
12.80%
发文量
2347
审稿时长
43 days
期刊介绍: Separation and Purification Technology is a premier journal committed to sharing innovative methods for separation and purification in chemical and environmental engineering, encompassing both homogeneous solutions and heterogeneous mixtures. Our scope includes the separation and/or purification of liquids, vapors, and gases, as well as carbon capture and separation techniques. However, it's important to note that methods solely intended for analytical purposes are not within the scope of the journal. Additionally, disciplines such as soil science, polymer science, and metallurgy fall outside the purview of Separation and Purification Technology. Join us in advancing the field of separation and purification methods for sustainable solutions in chemical and environmental engineering.
文献相关原料
公司名称
产品信息
阿拉丁
Tetrabutylammonium bromide (TBAB)
阿拉丁
Tetrabutylammonium chloride
阿拉丁
Tetrapropylammonium chloride
阿拉丁
Tetraethylammonium chloride
阿拉丁
Tetrabutylammonium hydrogen sulfate
阿拉丁
Tetrabutylphosphonium bromide
阿拉丁
Betaine hydrochloride (betaine·HCl)
阿拉丁
Choline chloride (ChCl)
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