Risk of carcinomas among children and adolescents with birth defects

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-01-22 DOI:10.1016/j.canep.2025.102748

Jeremy M. Schraw , Ji Yun Tark , Tania A. Desrosiers , Tiffany M. Chambers , Charles J. Shumate , Wendy N. Nembhard , Mahsa M. Yazdy , Eirini Nestoridi , Mary Frances Wedekind Malone , Theodore W. Laetsch , Brigitte C. Widemann , Amanda E. Janitz , Jean Paul Tanner , Russell S. Kirby , Jason L. Salemi , Logan G. Spector , Chad D. Huff , Sharon E. Plon , Philip J. Lupo

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引用次数: 0

Abstract

Background

Birth defects are associated with childhood cancer, but little is known regarding pediatric carcinomas, a group of especially rare tumors.

Methods

We used Cox proportional hazards regression to estimate the hazard ratio (HR) and 95 % confidence interval (CI) for any carcinoma, as well as thyroid, hepatocellular, and renal carcinoma specifically, up to 18 years of age among children with major, non-syndromic anomalies or chromosomal/genetic syndromes, relative to unaffected children.

Results

Our registry-linkage study included nine states and 21,933,476 children between 1990 and 2018: 641,827 with non-syndromic anomalies, and 49,619 with syndromes. Carcinomas were diagnosed in 833 children, including 35 with non-syndromic anomalies and eight with syndromes. The hazard of carcinoma was increased both among children with non-syndromic anomalies (HR: 1.7, CI: 1.2–2.4; N = 35) and syndromes (HR: 4.7, CI: 2.3–9.5; N = 7). Hepatocellular carcinoma was associated with non-syndromic anomalies (HR: 4.6, CI: 2.2–9.7; N = 8) and syndromes (HR: 8.0, CI: 1.1–58.1; N < 5). The hazard of renal carcinoma was markedly increased in children with tuberous sclerosis (HR 59.6, CI: 23.7–149.5; N = 5), a known cause of renal cancer. Thyroid carcinoma was not associated with non-syndromic anomalies or syndromes.

Conclusion

Birth defects are associated with hepatocellular and renal carcinoma in children.

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有先天缺陷的儿童和青少年患癌症的风险。

背景：出生缺陷与儿童癌症有关，但对儿童癌（一组特别罕见的肿瘤）知之甚少。方法：我们使用Cox比例风险回归来估计任何癌症的风险比（HR）和95% %置信区间（CI），特别是甲状腺癌、肝细胞癌和肾癌，在18岁以下有重大、非综合征性异常或染色体/遗传综合征的儿童中，相对于未受影响的儿童。结果：我们的登记关联研究包括1990年至2018年期间9个州和21,933,476名儿童：641,827名患有非综合征性异常，49,619名患有综合征。833名儿童被诊断为癌症，其中35名患有非综合征性异常，8名患有综合征。非综合征性异常儿童患癌的风险均增加(HR: 1.7, CI: 1.2-2.4；N = 35)和综合征(HR: 4.7, CI: 2.3-9.5；N = 7)。肝细胞癌与非综合征性异常相关(HR: 4.6, CI: 2.2-9.7；N = 8)和综合征(HR: 8.0, CI: 1.1-58.1；N 结论：出生缺陷与儿童肝细胞癌和肾癌相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.