Associations of insulin resistance estimated by glucose disposal rate with frailty progression

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2025-01-17 DOI:10.1016/j.archger.2025.105764

Jiayu Sun , Xiaoming Guo , Wenxin Guo , Yanlong Li , Junzhe Han , Bin Yang , Lina Meng , Yang Liu

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引用次数: 0

Abstract

Objectives

To investigate the relationship between estimated glucose disposal rates (eGDR) and the progression of frailty, using longitudinal data.

Methods

We analyzed four waves of data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018, involving 6,778 middle-aged and older adults. eGDR was calculated using a specific formula, categorizing participants into high and low eGDR groups based on the lowest quartile (8.5). Frailty status was assessed using the frailty index (FI). Linear mixed-effects models were employed to analyze the association between eGDR and frailty progression, as well as the impact of transitions in eGDR.

Results

We found that the baseline FI was significantly higher in the low eGDR group compared to the high eGDR group. Furthermore, participants in the low eGDR group exhibited a faster progression of frailty, compared to those in the high eGDR group. Among non-frail participants at baseline, the association between low eGDR and accelerated frailty progression was even more pronounced. Further analysis revealed that, compared to participants who maintained a stable high eGDR, those who transitioned from high to low eGDR and those who consistently remained in the low eGDR group both experienced significantly accelerated frailty progression. On the contrary, participants who transitioned from low to high eGDR did not show a significant acceleration in frailty progression compared to those who consistently maintained a high eGDR.

Conclusion

Low eGDR is linked to accelerated frailty progression in middle-aged and older Chinese adults. Transitioning from low to high eGDR may mitigate this progression, highlighting the importance of eGDR in frailty management.

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.