Considerations and expectations for the administration of dispersible arpraziquantel to young children: a landscape analysis.

IF 2.3 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Johanna Kurscheid, Andrea Buhl, Erica Westenberg, Marta Sólveig Palmeirim, Andrea Sylvia Winkler, Peter Steinmann, Nora Monnier
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引用次数: 0

Abstract

Schistosomiasis is a serious public health problem in many African countries and beyond. Preventive chemotherapy with praziquantel is a successful public health intervention that is recommended for all communities at risk, commonly reached through large-scale mass drug administration campaigns. However, preschool-age children are currently not routinely targeted for treatment due to operational challenges related to dosing and administration with the standard drug formulation. In response to the need for a suitable, child-friendly treatment, the multistakeholder Pediatric Praziquantel Consortium has developed a novel dispersible tablet with improved taste and smaller size. To prepare the introduction and inform future uptake of the novel paediatric formulation in endemic countries, we conducted a landscape analysis to explore perspectives, opinions and experiences of key stakeholders on operational and practical issues in relation to drug dosing and administration. Our findings confirm that child-friendly drug formulations mitigate several operational constraints related to the dosing and administration in young children. The introduction of this novel child health intervention into routine platforms and programs requires solid training and careful communication by engaging with communities, caregivers, healthcare workers and decision-makers to ensure acceptance and future uptake of treatment.

分散吡喹酮给幼儿用药的考虑和期望:景观分析。
血吸虫病在许多非洲国家和其他地区是一个严重的公共卫生问题。吡喹酮预防性化疗是一种成功的公共卫生干预措施,建议所有高危社区采用,通常通过大规模大规模给药运动来实现。然而,由于与标准药物配方的剂量和给药相关的操作挑战,学龄前儿童目前不是常规治疗的目标。为了满足对合适的儿童友好型治疗的需求,多利益相关方儿科吡喹酮联盟开发了一种新型分散片剂,其口感更好,尺寸更小。为了准备在流行国家引进这种新型儿科制剂并为今后采用提供信息,我们进行了一项概况分析,以探讨主要利益攸关方在药物剂量和给药方面的业务和实际问题上的观点、意见和经验。我们的研究结果证实,儿童友好型药物配方减轻了与幼儿剂量和给药有关的几个操作限制。将这种新颖的儿童健康干预措施引入常规平台和规划,需要与社区、护理人员、卫生保健工作者和决策者进行扎实的培训和认真的沟通,以确保接受和未来接受治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Health
International Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
4.50
自引率
0.00%
发文量
83
审稿时长
>12 weeks
期刊介绍: International Health is an official journal of the Royal Society of Tropical Medicine and Hygiene. It publishes original, peer-reviewed articles and reviews on all aspects of global health including the social and economic aspects of communicable and non-communicable diseases, health systems research, policy and implementation, and the evaluation of disease control programmes and healthcare delivery solutions. It aims to stimulate scientific and policy debate and provide a forum for analysis and opinion sharing for individuals and organisations engaged in all areas of global health.
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