Nasopharyngeal carcinoma with unusual metastatic spread to the spine and meninges: a case report with literature review.

IF 0.4 Q4 SURGERY
Journal of Surgical Case Reports Pub Date : 2025-01-23 eCollection Date: 2025-01-01 DOI:10.1093/jscr/rjaf022
Salma Swadi Yassen, Sajjad Ghanim Al-Badri, Ali Naser Aldarawsha, Mohamed Samy Elazab, Asdah Alawad, Ameer Dhahir Hameedi, Abdulrahman Khaldoon Hamid, Hussein Mohsin Hasan, Nabeel Al-Fatlawi, Hasan Ali Asghar
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引用次数: 0

Abstract

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy commonly associated with Epstein-Barr virus infection. While bone, liver, and lung metastases are well-documented, central nervous system (CNS) involvement, particularly spinal and meningeal metastases, is extremely rare. We present a 41-year-old male with nasal obstruction and diplopia, diagnosed with locally advanced NPC. After treatment with chemotherapy and intensity-modulated radiotherapy, the patient achieved excellent locoregional control. However, months later, he developed persistent back pain, and imaging revealed metastatic deposits in the spine and meninges. Histopathological analysis confirmed metastatic NPC despite resolution of the primary tumor. The patient received palliative radiotherapy and intrathecal chemotherapy, but disease progression highlighted the aggressive nature and poor prognosis of CNS metastases in NPC. This case underscores the need for advanced imaging, histological confirmation, and tailored therapies in managing rare NPC metastases, with long-term follow-up and innovative therapies critical for improving outcomes in advanced disease.

鼻咽癌异常转移扩散至脊柱及脑膜:1例报告并文献复习。
鼻咽癌(NPC)是一种上皮恶性肿瘤,通常与eb病毒感染有关。虽然骨、肝和肺转移有充分的文献记载,但中枢神经系统(CNS)的转移,特别是脊髓和脑膜转移,是极其罕见的。我们报告一位41岁男性,患有鼻塞和复视,诊断为局部晚期鼻咽癌。经化疗和调强放疗治疗后,患者获得了良好的局部控制。然而,几个月后,他出现了持续的背部疼痛,影像学显示脊柱和脑膜有转移性沉积。尽管原发肿瘤已消退,但组织病理学分析证实为转移性鼻咽癌。患者接受了姑息性放疗和鞘内化疗,但疾病进展突出了鼻咽癌中枢神经系统转移的侵袭性和不良预后。该病例强调了在治疗罕见的鼻咽癌转移时需要先进的影像学、组织学确认和量身定制的治疗方法,长期随访和创新治疗对于改善晚期疾病的预后至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.70
自引率
0.00%
发文量
559
审稿时长
11 weeks
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