A multifunctional photothermal electrospun PLGA/MoS₂@Pd nanofiber membrane for diabetic wound healing.

IF 8.1 1区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Regenerative Biomaterials Pub Date : 2024-12-14 eCollection Date: 2025-01-01 DOI:10.1093/rb/rbae143

Zhengrong Chen, Quansheng Mo, Dandan Mo, Xiaomin Pei, Anru Liang, Jinhong Cai, Bo Zhou, Li Zheng, Hongmian Li, Feiying Yin, Jinmin Zhao

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引用次数: 0

Abstract

Injury caused by excess reactive oxygen species (ROS) may lead to susceptibility to bacterial infection and sustained inflammatory response, which are the major factors impeding diabetic wound healing. By utilizing optimal anti-inflammatory, antioxidant and antibacterial biomaterials for multifunctional wound dressings is critical in clinical applications. In this study, a novel electrospun PLGA/MoS₂@Pd nanofiber membrane was synthesized by encapsulating antioxidant and near-infrared (NIR) responsive MOS₂@Pd nanozymes in PLGA nanofibers to form a multifunctional dressing for diabetic wound repair. With excellent biocompatibility and hemostatic ability, this novel PLGA/MoS₂@Pd nanofiber membrane can effectively reduce oxidative stress damage and intracellular inflammatory factors expression in fibroblasts by scavenging ROS. Additionally, the PLGA/MoS₂@Pd nanofiber membrane exhibited favorable NIR-mediated photothermal antibacterial activity in vitro, with inhibition rates of 97.14% and 97.07% against Staphylococcus aureus (S.aureus) and Escherichia coli (E.coli), respectively. In a diabetic rat wound infection model, NIR-assisted PLGA/MoS₂@Pd nanofiber membrane effectively inhibited bacterial growth in the wound, reduced infection-induced inflammatory response, and promoted tissue epithelialization and collagen deposition, resulting in a wound healing rate of up to 98.5% on Day 14. This study highlighted the construction of a multifunctional nanofiber membrane platform and demonstrated its promising potential as a clinical dressing for diabetic wounds.

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用于糖尿病伤口愈合的多功能光热静电纺PLGA/MoS2@Pd纳米纤维膜。

过多的活性氧（ROS）引起的损伤可能导致细菌感染的易感性和持续的炎症反应，这是阻碍糖尿病创面愈合的主要因素。利用最佳的抗炎、抗氧化和抗菌生物材料制作多功能伤口敷料在临床应用中至关重要。在本研究中，通过在PLGA纳米纤维中包封抗氧化剂和近红外（NIR）响应MOS2@Pd纳米酶，合成了一种新型的静电纺PLGA/MoS2@Pd纳米纤维膜，形成了一种用于糖尿病伤口修复的多功能敷料。新型PLGA/MoS2@Pd纳米纤维膜具有良好的生物相容性和止血能力，可通过清除ROS有效降低成纤维细胞的氧化应激损伤和细胞内炎症因子的表达。此外，PLGA/MoS2@Pd纳米纤维膜具有良好的nir介导的体外光热抗菌活性，对金黄色葡萄球菌（S.aureus）和大肠杆菌（E.coli）的抑制率分别为97.14%和97.07%。在糖尿病大鼠创面感染模型中，nir辅助的PLGA/MoS2@Pd纳米纤维膜有效抑制创面细菌生长，减少感染诱导的炎症反应，促进组织上皮化和胶原沉积，创面愈合率在第14天高达98.5%。本研究强调了多功能纳米纤维膜平台的构建，并展示了其作为糖尿病伤口临床敷料的潜力。

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来源期刊

Regenerative Biomaterials Materials Science-Biomaterials

CiteScore

7.90

自引率

16.40%

发文量

审稿时长

10 weeks

期刊介绍： Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.