Precision control of cellular functions with a temperature-sensitive protein

IF 36.1 1区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Nature Methods Pub Date : 2025-01-23 DOI:10.1038/s41592-024-02573-3

引用次数: 0

Abstract

Temperature-sensitive proteins would enable the remote control of cellular functions deep within tissues, although few such proteins have been characterized. Melt is a protein that reversibly clusters and translocates to the membrane in response to small temperature changes, enabling flexible regulation of cellular processes in vitro and in vivo.

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用温度敏感蛋白精确控制细胞功能。

温度敏感蛋白可以远程控制组织深处的细胞功能，尽管很少有这样的蛋白质被表征。熔体是一种蛋白质，可以在微小的温度变化下可逆地聚集和易位到膜上，从而可以灵活地调节体外和体内的细胞过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Methods 生物-生化研究方法

CiteScore

58.70

自引率

1.70%

发文量

326

审稿时长

1 months

期刊介绍： Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.