Nypa fruticans Wurmb Extract Recovered Compromised Immune Status Induced by Forced Swimming in a Mouse Model.

IF 2.5 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Gun-Dong Kim, Sang Hyuk Yoo, Ju Hye Song, Kyung Min Lim, Eun Yeong Lim, Ji Yeon Yoo, Da-Kyoung Lee, Yong-Baik Cho, Heong-Jun Yu, So-Young Lee, Hee Soon Shin
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Abstract

Nypa fruticans Wurmb is known to contain large amounts of polyphenols and flavonoids with antioxidative and anti-inflammatory effects. However, the biological and physiological functions of N. fruticans have not been scientifically investigated. Thus, we investigated the immunomodulatory effect of N. fruticans hot water extract (YSK-N) in mice using an immune compromised model established by forced swimming (FS). Intensive exercise decreased body weight, organ index, and various immunological parameters in FS mice. However, oral administration of YSK-N significantly restored the FS-induced decreases in body, thymus, and spleen weights, as well as the reduction in the numbers of white blood cells and lymphocytes in the whole blood of mice. Additionally, YSK-N increased splenic cell proliferation in the absence and presence of concanavalin A or lipopolysaccharide stimulation in a concentration-dependent manner. Notably, YSK-N enhanced the cytotoxic activity of natural killer cells against YAC-1 tumor cells under immunosuppressive conditions. Furthermore, YSK-N supplementation reverted the FS-induced downregulation in immunoglobulin production and Il2, Il6, Il12, Ifnγ, Gzmb, and Prf1 mRNA expression. Therefore, our observations suggested that YSK-N promotes immune function and has potential as an immunomodulatory agent.

山茱萸提取物可恢复强迫游泳诱导的小鼠免疫功能低下。
众所周知,果芽草含有大量的多酚和类黄酮,具有抗氧化和抗炎作用。然而,其生物学和生理功能尚未得到科学研究。因此,我们采用强迫游泳(FS)法建立小鼠免疫功能受损模型,研究了水果糖热水提取物(YSK-N)对小鼠的免疫调节作用。剧烈运动可降低FS小鼠的体重、器官指数和各种免疫参数。然而,口服YSK-N可显著恢复fs引起的小鼠体、胸腺和脾脏重量的下降,以及全血白细胞和淋巴细胞数量的减少。此外,YSK-N在没有或存在豆豆蛋白A或脂多糖刺激的情况下以浓度依赖的方式增加脾细胞增殖。值得注意的是,YSK-N增强了免疫抑制条件下自然杀伤细胞对YAC-1肿瘤细胞的细胞毒活性。此外,补充YSK-N恢复了fs诱导的免疫球蛋白产生和Il2、Il6、Il12、Ifnγ、Gzmb和Prf1 mRNA表达的下调。因此,我们的观察结果表明,YSK-N促进免疫功能,具有作为免疫调节剂的潜力。
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来源期刊
Journal of microbiology and biotechnology
Journal of microbiology and biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MICROBIOLOGY
CiteScore
5.50
自引率
3.60%
发文量
151
审稿时长
2 months
期刊介绍: The Journal of Microbiology and Biotechnology (JMB) is a monthly international journal devoted to the advancement and dissemination of scientific knowledge pertaining to microbiology, biotechnology, and related academic disciplines. It covers various scientific and technological aspects of Molecular and Cellular Microbiology, Environmental Microbiology and Biotechnology, Food Biotechnology, and Biotechnology and Bioengineering (subcategories are listed below). Launched in March 1991, the JMB is published by the Korean Society for Microbiology and Biotechnology (KMB) and distributed worldwide.
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