Early insights of dengue virus serotype 3 (DENV-3) re-emergence in São Paulo, Brazil

IF 4 3区医学 Q2 VIROLOGY

Journal of Clinical Virology Pub Date : 2025-02-01 DOI:10.1016/j.jcv.2025.105763

Lívia Sacchetto , Victória Bernardi , Marini L. Brancini , Beatriz de C. Marques , Andreia Negri , Nikos Vasilakis , Cassia F. Estofolete , Maurício L. Nogueira

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引用次数: 0

Abstract

Background

In dengue hyperendemic regions, the evolution of the virus is marked by frequent virus introduction/reintroduction and clade replacement events, occasionally linked to an epidemic outbreak. From 2023 onwards, an increase in the detection of DENV-3 cases has been reported in different regions of Brazil. Thus, molecular and genomic surveillance of circulating DENV strains is crucial for public health preparedness and response efforts for the disease.

Objectives

This work aimed to characterize and provide preliminary insights into dengue virus serotype 3 (DENV-3) re-emergence in São Paulo state, Brazil.

Study design

We conducted active arbovirus molecular surveillance on samples from patients with acute febrile illness combined with next-generation sequencing and phylogenetic analyses.

Results

We detected and characterized DENV-3 circulation in São Paulo, Brazil, since late 2023. The genomes clustered within genomes recently (2022–2024) identified in Florida, the Caribbean region, and Brazil.

Conclusions

Our results demonstrate the resurgence of DENV-3 in the region since 2009, raising concerns about a potential outbreak in regions with a high epidemic history.

查看原文本刊更多论文

登革热血清3型病毒（DENV-3）在巴西圣保罗重新出现。

背景：在登革热高流行区，病毒的演变以频繁的病毒引入/再引入和进化支替换事件为特征，偶尔与流行病暴发有关。从2023年起，巴西不同地区报告的DENV-3病例的发现有所增加。因此，对流行DENV毒株进行分子和基因组监测对于该疾病的公共卫生准备和应对工作至关重要。目的：本研究旨在对巴西圣保罗州再次出现的登革热病毒血清3型（DENV-3）进行表征并提供初步见解。研究设计：我们对急性发热性疾病患者的样本进行了活性虫媒病毒分子监测，并结合了下一代测序和系统发育分析。结果：自2023年底以来，我们在巴西圣保罗检测并表征了DENV-3循环。这些基因组最近（2022-2024）聚集在佛罗里达、加勒比地区和巴西发现的基因组中。结论：我们的研究结果表明，DENV-3自2009年以来在该地区死灰复燃，这引起了人们对在高流行史地区可能爆发疫情的担忧。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Virology 医学-病毒学

CiteScore

22.70

自引率

1.10%

发文量

149

审稿时长

24 days

期刊介绍： The Journal of Clinical Virology, an esteemed international publication, serves as the official journal for both the Pan American Society for Clinical Virology and The European Society for Clinical Virology. Dedicated to advancing the understanding of human virology in clinical settings, the Journal of Clinical Virology focuses on disseminating research papers and reviews pertaining to the clinical aspects of virology. Its scope encompasses articles discussing diagnostic methodologies and virus-induced clinical conditions, with an emphasis on practicality and relevance to clinical practice. The journal publishes on topics that include: • new diagnostic technologies • nucleic acid amplification and serologic testing • targeted and metagenomic next-generation sequencing • emerging pandemic viral threats • respiratory viruses • transplant viruses • chronic viral infections • cancer-associated viruses • gastrointestinal viruses • central nervous system viruses • one health (excludes animal health)