{"title":"Opportunities for microphysiological systems from the view of Japanese industries.","authors":"Hitoshi Naraoka, Takuma Iguchi, Kosuke Harada, Toru Usui, Yoshiaki Suwa, Masamitsu Ando, Takeshi Sakura, Tomoki Ohkubo","doi":"10.1016/j.dmpk.2024.101034","DOIUrl":null,"url":null,"abstract":"<p><p>Regulatory authorities and pharmaceutical companies in Europe and the United States have paid attention to microphysiological systems (MPS), and various consortia and academic societies have been established. They are actively working toward their implementation under individual company or regulatory acceptance. In Japan, some AMED projects, academic societies, and consortia have also been established and activities have begun. This article focuses on domestic and international trends regarding MPS, especially on Japanese industries related to MPS, and describes the current status, challenges, and prospects of Japanese pharmaceutical companies, CROs, Food company, and MPS-related product development companies including the results of a survey conducted by CSAHi-MPS, an industrial MPS consortium in Japan.</p>","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"60 ","pages":"101034"},"PeriodicalIF":2.7000,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Metabolism and Pharmacokinetics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.dmpk.2024.101034","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Regulatory authorities and pharmaceutical companies in Europe and the United States have paid attention to microphysiological systems (MPS), and various consortia and academic societies have been established. They are actively working toward their implementation under individual company or regulatory acceptance. In Japan, some AMED projects, academic societies, and consortia have also been established and activities have begun. This article focuses on domestic and international trends regarding MPS, especially on Japanese industries related to MPS, and describes the current status, challenges, and prospects of Japanese pharmaceutical companies, CROs, Food company, and MPS-related product development companies including the results of a survey conducted by CSAHi-MPS, an industrial MPS consortium in Japan.
期刊介绍：
DMPK publishes original and innovative scientific papers that address topics broadly related to xenobiotics. The term xenobiotic includes medicinal as well as environmental and agricultural chemicals and macromolecules. The journal is organized into sections as follows:
- Drug metabolism / Biotransformation
- Pharmacokinetics and pharmacodynamics
- Toxicokinetics and toxicodynamics
- Drug-drug interaction / Drug-food interaction
- Mechanism of drug absorption and disposition (including transporter)
- Drug delivery system
- Clinical pharmacy and pharmacology
- Analytical method
- Factors affecting drug metabolism and transport
- Expression of genes for drug-metabolizing enzymes and transporters
- Pharmacogenetics and pharmacogenomics
- Pharmacoepidemiology.
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