Bolstered bone regeneration by multiscale customized magnesium scaffolds with hierarchical structures and tempered degradation

IF 18 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Zehui Lv , Bo Peng , Yu Ye , Haojing Xu , Xuejie Cai , Jinge Liu , Jiabao Dai , Yixin Bian , Peng Wen , Xisheng Weng
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Abstract

Addressing irregular bone defects is a formidable clinical challenge, as traditional scaffolds frequently fail to meet the complex requirements of bone regeneration, resulting in suboptimal healing. This study introduces a novel 3D-printed magnesium scaffold with hierarchical structure (macro-, meso-, and nano-scales) and tempered degradation (microscale), intricately customized at multiple scales to bolster bone regeneration according to patient-specific needs. For the hierarchical structure, at the macroscale, it can feature anatomic geometries for seamless integration with the bone defect; The mesoscale pores are devised with optimized curvature and size, providing an adequate mechanical response as well as promoting cellular proliferation and vascularization, essential for natural bone mimicry; The nanoscale textured surface is enriched with a layered double hydroxide membrane, augmenting bioactivity and osteointegration. Moreover, microscale enhancements involve a dual-layer coating of high-temperature oxidized film and hydrotalcite, offering a robust shield against fast degradation. Eventually, this scaffold demonstrates superior geometrical characteristics, load-bearing capacity, and degradation performance, significantly outperforming traditional scaffolds based on in vitro and in vivo assessments, marking a breakthrough in repairing customized bone defects.

Abstract Image

分级结构和缓降解多尺度定制镁支架的骨再生支持。
治疗不规则骨缺损是一项艰巨的临床挑战,因为传统的支架经常不能满足骨再生的复杂要求,导致愈合不理想。本研究介绍了一种新型的3d打印镁支架,它具有层次结构(宏观、中观和纳米尺度)和调节降解(微观尺度),可以根据患者的具体需求在多个尺度上复杂定制,以支持骨再生。对于层次结构,在宏观上,它可以具有与骨缺损无缝集成的解剖几何形状;中尺度孔隙具有优化的曲率和大小,提供适当的机械响应,并促进细胞增殖和血管形成,这对自然骨模拟至关重要;纳米级纹理表面富含层状双氢氧化物膜,增强生物活性和骨整合。此外,微尺度的增强包括高温氧化膜和水滑石的双层涂层,提供抗快速降解的强大屏蔽。最终,基于体外和体内评估,该支架显示出优越的几何特征、承载能力和降解性能,显著优于传统支架,标志着定制骨缺损修复的突破。
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来源期刊
Bioactive Materials
Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
28.00
自引率
6.30%
发文量
436
审稿时长
20 days
期刊介绍: Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.
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