Recent advance for enantiorecognition of chiral drugs sensing: Electrochemical, electrochemiluminescent and photoelectrochemical application

IF 10.7 1区生物学 Q1 BIOPHYSICS

Biosensors and Bioelectronics Pub Date : 2025-01-08 DOI:10.1016/j.bios.2025.117141

Qianxiu Pan , Hong Guan , Wenjing Xu , Jingjing Zhao , Yan Liu , Lin Cui , Jin Zhou

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引用次数: 0

Abstract

Chiral isomers show different behaviours and properties in physiological activities. It is of great significance to find productive approach to realize the recognition of enantiomers, which is a key issue in biochemical and pharmaceutical fields. Nowadays, chiral identification can be successfully achieved according to the discrepancies of special signals correlated with different enantiomers of multiple electrode structures. Electrochemical technologies have attracted wide interest in enantioselective analysis because of its unique merits, such as the economic and miniaturized instruments, simplified and environmental-friendly sample preparations. This review summarizes the development trends of electrochemical sensing in the enantiospecific analysis of chiral drugs, expounds the enantiospecific recognition mechanism between chiral selector and target enantiomers based on general electrochemical, electrochemiluminescent and photoelectrochemical sensors, respectively. In addition, this review attempts to predict the future application of electrochemical, electrochemiluminescent and photoelectrochemical-based technologies in the enantioselective recognition and detection.

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来源期刊

Biosensors and Bioelectronics 工程技术-电化学

CiteScore

20.80

自引率

7.10%

发文量

1006

审稿时长

29 days

期刊介绍： Biosensors & Bioelectronics, along with its open access companion journal Biosensors & Bioelectronics: X, is the leading international publication in the field of biosensors and bioelectronics. It covers research, design, development, and application of biosensors, which are analytical devices incorporating biological materials with physicochemical transducers. These devices, including sensors, DNA chips, electronic noses, and lab-on-a-chip, produce digital signals proportional to specific analytes. Examples include immunosensors and enzyme-based biosensors, applied in various fields such as medicine, environmental monitoring, and food industry. The journal also focuses on molecular and supramolecular structures for enhancing device performance.