Applicability of Fluidized Bed Crystallization for Separation of Enantiomers Forming Needle-Shaped Crystals

IF 3.5 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2025-01-23 DOI:10.1021/acs.oprd.4c00444

Jonathan Gänsch, Igor Gamm, Andreas Seidel-Morgenstern, Heike Lorenz

引用次数: 0

Abstract

Enantioselective fluidized bed crystallization (FBC) presents an attractive process concept for the separation of chiral compounds due to its continuous operation, high productivity, and narrow size distribution achievable. Here, we report the application related to the amino acid dl-threonine, characterized by a needle-like crystal shape when crystallized from aqueous solution. After demonstrating successful chiral resolution via FBC, the impact of the system’s specific crystal growth kinetics on the FBC performance is studied at pilot plant scale. The coupling of the anisotropic crystal growth with size-classification and fragmentation in the seeding bypass enables the continuous production of compact pure enantiomer crystals with narrow size distribution. The optimization potential of the seeding strategy and the flow rate on separation performance, product crystal shape, and process robustness is investigated as well.

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流化床结晶法分离针状对映体的适用性

对映选择性流化床结晶（FBC）以其连续操作、高生产率和可实现的粒度分布窄等优点，为手性化合物的分离提供了一个有吸引力的工艺概念。在这里，我们报道了与氨基酸dl-苏氨酸相关的应用，该氨基酸在水溶液中结晶时具有针状晶体形状。在通过FBC证明了成功的手性分辨率之后，在中试工厂规模上研究了系统的特定晶体生长动力学对FBC性能的影响。在播种旁路中，各向异性晶体生长与尺寸分级和破碎的耦合使得连续生产致密的纯对映体晶体具有狭窄的尺寸分布。研究了播种策略和流量对分离性能、产物结晶形状和工艺鲁棒性的影响。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.