Applicability of Fluidized Bed Crystallization for Separation of Enantiomers Forming Needle-Shaped Crystals

IF 3.1 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2025-01-23 DOI:10.1021/acs.oprd.4c00444

Jonathan Gänsch, Igor Gamm, Andreas Seidel-Morgenstern, Heike Lorenz

引用次数: 0

Abstract

Enantioselective fluidized bed crystallization (FBC) presents an attractive process concept for the separation of chiral compounds due to its continuous operation, high productivity, and narrow size distribution achievable. Here, we report the application related to the amino acid dl-threonine, characterized by a needle-like crystal shape when crystallized from aqueous solution. After demonstrating successful chiral resolution via FBC, the impact of the system’s specific crystal growth kinetics on the FBC performance is studied at pilot plant scale. The coupling of the anisotropic crystal growth with size-classification and fragmentation in the seeding bypass enables the continuous production of compact pure enantiomer crystals with narrow size distribution. The optimization potential of the seeding strategy and the flow rate on separation performance, product crystal shape, and process robustness is investigated as well.

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.