Epidemiology and genotypic diversity of duck hepatitis B virus identified from waterfowl in partial areas of Guangdong province, Southern China

IF 2.8 3区医学 Q3 VIROLOGY

Virology Pub Date : 2025-02-01 DOI:10.1016/j.virol.2025.110416

Xinyan Yao , Chaoxiang Jia , Anqi Li , Ting Qin , Dai Peng , Yingqian Han , Shuang Guo , Kai Zhong , Guoyu Yang , Yueying Wang , Heping Li

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引用次数: 0

Abstract

Duck Hepatitis B virus (DHBV) infection model is extensively utilized as an animal model for studying human hepatitis B virus infection and for comparative research. 557 liver samples from geese and ducks were collected in parts of Guangdong province, southern China. The overall prevalence of DHBV was 45.6% (254/557) in all samples. And the 27 complete genome sequences of DHBV strains in this study share 89.6%–100% genome-wide pairwise identity with previously identified DHBV genomes. Notably, DHBV-1, DHBV-2 and DHBV-3 of were found co-circulating among the waterfowl population in parts of Guangdong. More importantly, seven out of the 16 recombination events were determined involved DHBV sequences obtained in this study as major parent and minor parent, suggesting DHBV strains from Guangdong province play an important role in recombination events. Additionally, purifying selection was the dominant evolutionary pressure acting on the genomes of DHBV.

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来源期刊

Virology 医学-病毒学

CiteScore

6.00

自引率

0.00%

发文量

157

审稿时长

50 days

期刊介绍： Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.