Gradient disparities in allergy and the gut microbiome among rural, migrant, and urban populations across China

IF 3.9 2区 医学 Q2 ALLERGY
Wanjun Wang , Mo Xian , Ruchong Chen , Jing Li , Lulu Wu
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引用次数: 0

Abstract

Background

While much of the evidence linking the rapid urbanization and the increasing prevalence of allergen sensitization, but little is known regarding rural-to-urban migrants. The aim of this study was to identify the disparities in allergy, the gut microbiome and factors among native urban, migrating, and native rural Chinese.

Methods

We redesigned the dataset of the China Alliance of Research on Respiratory Allergic Disease secondary survey, and after stratified sampling, a subsample of 2422 subjects were enrolled for the analysis of a questionnaire, skin prick tests (SPT), and specific immunoglobulin E (sIgE) titer measurements against 8 common allergens. Fecal microbiotal composition was also sequenced by 16S rRNA and regression-based analyses with covariate adjustment applied.

Results

From urban to migrant and rural populations, IgE sensitization was predominantly directed against Dermatophagoides pteronyssinus (Der p). The titers of Der p-sIgE decreased sequentially across the 3 respective populations and co-sensitization to other allergens also showed a sequential decrease. Rural-to-urban migrants showed a low prevalence of Der p-SPT and Der p-sIgE initially, but developed substantial IgE titers and their gut microbiotal diversity, as well as species richness, appeared to change along with residential time spent in the urban area. High-fat diet, using a mattress, an SPT wheal size from Der p ≥ 6 mm, and duration of immigration >5 years were significantly associated with sIgE positivity in the migrants.

Conclusion

The Der p-sIgE responses and the composition of gut microbiota differs synchronously with extended living time in an urban area. Studies in immigrants provide a unique opportunities to evaluate the effects of environmental factors in the pathogenesis of allergic disorders.
中国农村、流动人口和城市人口过敏和肠道微生物组的梯度差异
背景:虽然许多证据表明快速城市化与过敏原致敏的日益流行有关,但对农村到城市的移民知之甚少。本研究的目的是确定本地城市、移民和农村中国人在过敏、肠道微生物群和因素方面的差异。方法:重新设计中国呼吸道变态反应性疾病研究联盟二次调查数据集,分层抽样后纳入2422名受试者,进行问卷调查、皮肤点刺试验(SPT)和8种常见过敏原特异性免疫球蛋白E (sIgE)效价测定。粪便微生物组成也采用16S rRNA测序和基于协变量调整的回归分析。结果:从城市人群到流动人群和农村人群,IgE致敏主要针对翼状皮屑(derophagoides pteronyssinus, Der p)。在3个人群中,Der p- sige滴度依次下降,对其他过敏原的共致敏也依次下降。从农村到城市的移民最初表现出较低的Der p-SPT和Der p-sIgE患病率,但发展出大量的IgE滴度,他们的肠道微生物多样性和物种丰富度似乎随着在城市地区居住的时间而变化。高脂肪饮食、使用床垫、SPT轮大小(≥6 mm)和移民时间(≥5年)与移民sIgE阳性显著相关。结论:城市居民的Der - p-sIgE反应和肠道菌群组成随着生活时间的延长而同步变化。对移民的研究为评估环境因素在过敏性疾病发病机制中的作用提供了一个独特的机会。
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来源期刊
World Allergy Organization Journal
World Allergy Organization Journal Immunology and Microbiology-Immunology
CiteScore
9.10
自引率
5.90%
发文量
91
审稿时长
9 weeks
期刊介绍: The official pubication of the World Allergy Organization, the World Allergy Organization Journal (WAOjournal) publishes original mechanistic, translational, and clinical research on the topics of allergy, asthma, anaphylaxis, and clincial immunology, as well as reviews, guidelines, and position papers that contribute to the improvement of patient care. WAOjournal publishes research on the growth of allergy prevalence within the scope of single countries, country comparisons, and practical global issues and regulations, or threats to the allergy specialty. The Journal invites the submissions of all authors interested in publishing on current global problems in allergy, asthma, anaphylaxis, and immunology. Of particular interest are the immunological consequences of climate change and the subsequent systematic transformations in food habits and their consequences for the allergy/immunology discipline.
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