Oncological Feasibility of Limited Neck Dissection in cN0 Supraglottic Laryngeal Cancer.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-01-23 DOI:10.1002/hed.28081

Sara Bassani, Giacomo Papi, Filippo Marani, Riccardo Nocini, Valentina Campagnari, Filippo Marchi, Marco Lionello, Chiara Varago, Alberto Paderno, Erika Crosetti, Francesco Mattioli, Edoardo Serafini, Matteo Fermi, Alessandro Rosti, Gerardo Petruzzi, Flaminia Campo, Elisa Bellini, Alberto Vito Marcuzzo, Chiara Angela Mineo, Giuseppe Mercante, Armando De Virgilio, Leone Giordano, Andrea Galli, Giuditta Mannelli, Luca Mazzetti, Gaetano Paludetti, Giorgia Rossi, Karol Zeleník, Daniel Marin Ramos, Rogèrio Aparecido Dedivitis, Giovanni Succo, Giancarlo Tirelli, Mario Bussi, Raul Pellini, Jacopo Galli, Giuseppe Spriano, Daniele Monzani, Giorgio Peretti, Andy Bertolin, Cesare Piazza, Daniele Marchioni, Livio Presutti, Gabriele Molteni

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引用次数: 0

Abstract

Background: Supraglottic squamous cell carcinoma (SCC) is a significant portion of head and neck cancers, with the management of clinically negative necks (cN0) through selective neck dissection (SND) being debated due to potential morbidities and low metastasis rates in levels IIb and IV.

Methods: This study is a retrospective, multicenter examination of the potential feasibility of limited neck dissection (LND), including only levels IIa and III in cN0 supraglottic SCC patients. It analyzed occult metastasis rates and explored relapse occurrences alongside potential predictors of lymph node metastasis.

Results: Among 425 patients, predominantly male (85.6%) with a mean age of 63 years, the occult metastasis rate was 28.9%, and 13.7% experienced relapses during a mean follow-up of 52 months. Advanced clinical stage, higher grading, and other risk factors emerged as predictors of occult lymph node metastasis at level IIb.

Conclusions: The study supports LND potential feasibility for cN0 supraglottic SCC, suggesting level IIb dissection can be omitted in specific early-stage cases to reduce morbidity without affecting outcomes.

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.