Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities

IF 13.9 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-01-22 DOI:10.1126/sciadv.adr8243

Haipeng Huang, Jiaqi Hou, Mingxiao Li, Fangchao Wei, Yilie Liao, Beidou Xi

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Abstract

Human health is being threatened by environmental microplastic (MP) pollution. MPs were detected in the bloodstream and multiple tissues of humans, disrupting the regular physiological processes of organs. Nanoscale plastics can breach the blood-brain barrier, leading to neurotoxic effects. How MPs cause brain functional irregularities remains unclear. This work uses high-depth imaging techniques to investigate the MPs within the brain in vivo. We show that circulating MPs are phagocytosed and lead these cells to obstruction in the capillaries of the brain cortex. These blockages as thrombus formation cause reduced blood flow and neurological abnormalities in mice. Our data reveal a mechanism by which MPs disrupt tissue function indirectly through regulation of cell obstruction and interference with local blood circulation, rather than direct tissue penetration. This revelation offers a lens through which to comprehend the toxicological implications of MPs that invade the bloodstream.

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血液中的微塑料会引起细胞阻塞，从而诱发脑血栓，并导致神经行为异常。

环境微塑料污染正威胁着人类健康。在人体的血液和多个组织中检测到MPs，扰乱了器官的正常生理过程。纳米级塑料可以破坏血脑屏障，导致神经毒性作用。MPs是如何导致大脑功能异常的还不清楚。这项工作使用高深度成像技术来研究体内大脑内的MPs。我们发现循环MPs被吞噬并导致这些细胞在大脑皮层的毛细血管中受阻。这些阻塞如血栓形成导致小鼠血流量减少和神经异常。我们的数据揭示了MPs通过调节细胞阻塞和干扰局部血液循环间接破坏组织功能的机制，而不是直接穿透组织。这一发现为理解MPs侵入血流的毒理学含义提供了一个视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.