Key glycometabolism during oocyte maturation and early embryonic development.

IF 3.7 3区 生物学 Q1 DEVELOPMENTAL BIOLOGY
Reproduction Pub Date : 2025-02-04 Print Date: 2025-03-01 DOI:10.1530/REP-24-0275
Yichuan Zhang, Tianjie Li, Yibo Wang, Yang Yu
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引用次数: 0

Abstract

In brief: Glucose metabolism is central to the successful progression from oocyte maturation to blastocyst formation, influencing not only energy production but also key developmental decisions and epigenetic regulation. This review uncovers the intricate interplay between glucose, fatty acids, amino acids and nucleotides, highlighting their crucial roles in early embryonic development and exploring how noninvasive metabolic monitoring can revolutionize embryo selection and personalized assisted reproductive technologies, offering new hope for fertility treatments.

Abstract: In recent decades, it has become increasingly clear that mammalian gametes and early embryos are highly sensitive to metabolic substrates. With advances in single-cell sequencing, metabolomics and bioinformatics, we now recognize that metabolic pathways not only meet cellular energy demands but also play a critical role in cell proliferation, differentiation and fate determination. Investigating metabolic processes during oocyte maturation and early embryonic development is thus essential to advancing reproductive medicine and embryology. This review highlights the intricate metabolic pathways, particularly glucose metabolism, that drive the transition from an oocyte to an embryo. These processes involve a complex interaction of signaling pathways, nutrient availability and environmental factors, with glucose metabolism not only providing essential energy but also offering a variety of metabolic substrates and intermediates that regulate developmental events, influence cell signaling and impact epigenetic modifications. This article emphasizes that future research will focus on regulating maternal metabolic environments and noninvasive metabolic monitoring of embryonic systems, particularly glucose metabolism, with promising opportunities to improve embryo selection and personalized assisted reproductive technologies, ultimately enhancing fertility treatment outcomes.

卵母细胞成熟和早期胚胎发育过程中的关键糖代谢。
近几十年来,越来越清楚的是,哺乳动物配子和早期胚胎对代谢底物高度敏感。随着单细胞测序、代谢组学和生物信息学的进步,我们现在认识到代谢途径不仅满足细胞能量需求,而且在细胞增殖、分化和命运决定中起着关键作用。因此,研究卵母细胞成熟和早期胚胎发育过程中的代谢过程对推进生殖医学和胚胎学至关重要。这篇综述强调了复杂的代谢途径,特别是葡萄糖代谢,驱动从卵母细胞到胚胎的转变。这些过程涉及信号通路、营养可利用性和环境因素的复杂相互作用,葡萄糖代谢不仅提供必需的能量,还提供各种代谢底物和中间体,调节发育事件、影响细胞信号传导和影响表观遗传修饰。本文强调,未来的研究将集中在调节母体代谢环境和胚胎系统无创代谢监测,特别是葡萄糖代谢,有希望改善胚胎选择和个性化辅助生殖技术,最终提高生育治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reproduction
Reproduction 生物-发育生物学
CiteScore
7.40
自引率
2.60%
发文量
199
审稿时长
4-8 weeks
期刊介绍: Reproduction is the official journal of the Society of Reproduction and Fertility (SRF). It was formed in 2001 when the Society merged its two journals, the Journal of Reproduction and Fertility and Reviews of Reproduction. Reproduction publishes original research articles and topical reviews on the subject of reproductive and developmental biology, and reproductive medicine. The journal will consider publication of high-quality meta-analyses; these should be submitted to the research papers category. The journal considers studies in humans and all animal species, and will publish clinical studies if they advance our understanding of the underlying causes and/or mechanisms of disease. Scientific excellence and broad interest to our readership are the most important criteria during the peer review process. The journal publishes articles that make a clear advance in the field, whether of mechanistic, descriptive or technical focus. Articles that substantiate new or controversial reports are welcomed if they are noteworthy and advance the field. Topics include, but are not limited to, reproductive immunology, reproductive toxicology, stem cells, environmental effects on reproductive potential and health (eg obesity), extracellular vesicles, fertility preservation and epigenetic effects on reproductive and developmental processes.
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