MRI detects tubulointerstitial changes in mouse models of radiation-induced nephropathy.

IF 3 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance in Medicine Pub Date : 2025-01-23 DOI:10.1002/mrm.30443

Julia Stabinska, Joe Piccolo, Anupriya Chhabra, Ioanna Liatsou, Kathy Gabrielson, Zhi Li, Zinia Mohanta, Farzad Sedaghat, Robert F Hobbs, George Sgouros, Michael T McMahon

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引用次数: 0

Abstract

Purpose: We hypothesized that radiation-induced tubulointerstitial changes in the kidney can be assessed using MRI-based T₂ relaxation time measurements.

Methods: We performed MRI, histology, and serum biochemistry in two mouse models of radiation nephropathy: one involving external beam radiotherapy and the other using internal irradiation with an α-particle-emitting actinium-225 radiolabeled antibody. We compared the mean T₂ values of different renal compartments between control and external beam radiotherapy or α-particle-emitting actinium-225 radiolabeled antibody-treated groups and between the two radiation-treated groups using a Wilcoxon rank-sum test.

Results: Significantly higher T₂ values were found in the cortex and outer stripe of the outer medulla in all treated animals compared with the control group (p < 0.05). In addition, these changes in T₂ were observed before any changes in serum parameters, animal body weight, and kidney volume occurred.

Conclusion: T₂ mapping is sensitive to radiation-induced tubulointerstitial changes in the kidney.

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来源期刊

Magnetic Resonance in Medicine 医学-核医学

CiteScore

6.70

自引率

24.20%

发文量

376

审稿时长

2-4 weeks

期刊介绍： Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.