MRI detects tubulointerstitial changes in mouse models of radiation-induced nephropathy

IF 3 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance in Medicine Pub Date : 2025-01-23 DOI:10.1002/mrm.30443

Julia Stabinska, Joe Piccolo, Anupriya Chhabra, Ioanna Liatsou, Kathy Gabrielson, Zhi Li, Zinia Mohanta, Farzad Sedaghat, Robert F. Hobbs, George Sgouros, Michael T. McMahon

{"title":"MRI detects tubulointerstitial changes in mouse models of radiation-induced nephropathy","authors":"Julia Stabinska, Joe Piccolo, Anupriya Chhabra, Ioanna Liatsou, Kathy Gabrielson, Zhi Li, Zinia Mohanta, Farzad Sedaghat, Robert F. Hobbs, George Sgouros, Michael T. McMahon","doi":"10.1002/mrm.30443","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Purpose</h3>\n \n <p>We hypothesized that radiation-induced tubulointerstitial changes in the kidney can be assessed using MRI-based T<sub>2</sub> relaxation time measurements.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We performed MRI, histology, and serum biochemistry in two mouse models of radiation nephropathy: one involving external beam radiotherapy and the other using internal irradiation with an α-particle-emitting actinium-225 radiolabeled antibody. We compared the mean T<sub>2</sub> values of different renal compartments between control and external beam radiotherapy or α-particle-emitting actinium-225 radiolabeled antibody–treated groups and between the two radiation-treated groups using a Wilcoxon rank-sum test.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Significantly higher T<sub>2</sub> values were found in the cortex and outer stripe of the outer medulla in all treated animals compared with the control group (<i>p</i> < 0.05). In addition, these changes in T<sub>2</sub> were observed before any changes in serum parameters, animal body weight, and kidney volume occurred.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>T<sub>2</sub> mapping is sensitive to radiation-induced tubulointerstitial changes in the kidney.</p>\n </section>\n </div>","PeriodicalId":18065,"journal":{"name":"Magnetic Resonance in Medicine","volume":"94 1","pages":"251-261"},"PeriodicalIF":3.0000,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Magnetic Resonance in Medicine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mrm.30443","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose

We hypothesized that radiation-induced tubulointerstitial changes in the kidney can be assessed using MRI-based T₂ relaxation time measurements.

Methods

We performed MRI, histology, and serum biochemistry in two mouse models of radiation nephropathy: one involving external beam radiotherapy and the other using internal irradiation with an α-particle-emitting actinium-225 radiolabeled antibody. We compared the mean T₂ values of different renal compartments between control and external beam radiotherapy or α-particle-emitting actinium-225 radiolabeled antibody–treated groups and between the two radiation-treated groups using a Wilcoxon rank-sum test.

Results

Significantly higher T₂ values were found in the cortex and outer stripe of the outer medulla in all treated animals compared with the control group (p < 0.05). In addition, these changes in T₂ were observed before any changes in serum parameters, animal body weight, and kidney volume occurred.

Conclusion

T₂ mapping is sensitive to radiation-induced tubulointerstitial changes in the kidney.

查看原文本刊更多论文

MRI检测放射肾病小鼠模型的小管间质改变。

目的：我们假设辐射引起的肾小管间质改变可以通过基于mri的T2弛豫时间测量来评估。方法：我们对两种放射性肾病小鼠模型进行了MRI、组织学和血清生化检查：一种采用外射束放疗，另一种采用α-粒子发射锕-225放射标记抗体内照射。我们使用Wilcoxon秩和检验比较了对照组和外部放射束放疗组、α-粒子发射锕-225放射标记抗体治疗组以及两个放疗组之间不同肾室的平均T2值。结果：与对照组相比，治疗组大鼠外髓质皮层及外条T2值均显著升高（p < 0.05），血清参数、体重、肾容量均未发生变化。结论：T2定位对辐射引起的肾小管间质改变敏感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Magnetic Resonance in Medicine 医学-核医学

CiteScore

6.70

自引率

24.20%

发文量

376

审稿时长

2-4 weeks

期刊介绍： Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.