Exploring the Therapeutic Potential of 1,3-Thiazole: A Decade Overview.

IF 1.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Medicinal Chemistry Pub Date : 2025-01-22 DOI:10.2174/0115734064365060250116103320

Ajit Manchare, Swapnali Parit, Mukta Lele, Navnath Hatvate

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Abstract

The escalating prevalence of lifestyle and microbial diseases poses a significant threat to human well-being, necessitating the discovery and development of novel drugs with distinct modes of action. Addressing this challenge involves employing innovative strategies, and one current approach involves utilizing heterocyclic compounds to synthesize hybrid molecules. These hybrids have resulted from the fusion of two or more bioactive heterocyclic moieties into a single molecule. The focus of this review revolves around the strategic incorporation of heterocycles, particularly thiazole derivatives. Thiazole derivatives, due to their unique structural features, are explored in depth within this review paper. The paper comprehensively outlines diverse hybridization strategies of thiazole derivatives, highlighting their vibrant biological activities mainly in the last decade, 2014-2024. By presenting an extensive overview, the review aims to provide valuable insights into the potential of thiazole derivatives as promising candidates for drug development. The insights garnered from this paper are expected to offer valuable guidance for future drug design endeavors, providing a foundation for developing novel and effective drugs to combat lifestyle diseases and microbial resistance.

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探索1,3-噻唑的治疗潜力：十年综述。

生活方式和微生物疾病的日益流行对人类福祉构成重大威胁，因此有必要发现和开发具有不同作用方式的新型药物。解决这一挑战需要采用创新的策略，目前的一种方法是利用杂环化合物合成杂化分子。这些杂交种是由两个或多个具有生物活性的杂环片段融合成一个分子而产生的。本综述的重点是围绕杂环化合物，特别是噻唑衍生物的战略性结合。由于其独特的结构特征，本文对噻唑类衍生物进行了深入的探讨。本文全面概述了噻唑类衍生物的多种杂交策略，重点介绍了它们在过去十年（2014-2024年）中活跃的生物活性。通过广泛的概述，本综述旨在为噻唑衍生物作为药物开发的有前途的候选药物的潜力提供有价值的见解。本文所获得的见解有望为未来的药物设计工作提供有价值的指导，为开发对抗生活方式疾病和微生物耐药性的新型有效药物提供基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicinal Chemistry 医学-医药化学

CiteScore

4.30

自引率

4.30%

发文量

109

审稿时长

12 months

期刊介绍： Aims & Scope Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.